SLC12A7

SLC12A7
Identifiers
Aliases	SLC12A7, KCC4, solute carrier family 12 member 7
External IDs	MGI: 1342283 HomoloGene: 21312 GeneCards: SLC12A7
Gene ontology Molecular function • transporter activity • cation:chloride symporter activity • potassium ion symporter activity • symporter activity • protein kinase binding • potassium:chloride symporter activity Cellular component • integral component of membrane • integral component of plasma membrane • membrane • plasma membrane Biological process • potassium ion transport • cell volume homeostasis • chloride transmembrane transport • chemical synaptic transmission • potassium ion transmembrane transport • transmembrane transport • ion transport • transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10723	20499
Ensembl	n/a	ENSMUSG00000017756
UniProt	Q9Y666	Q9WVL3
RefSeq (mRNA)	NM_006598	NM_011390
RefSeq (protein)	NP_006589.2	NP_035520.1
Location (UCSC)	Chr 5: 1.05 – 1.11 Mb	Chr 13: 73.76 – 73.82 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Solute carrier family 12 member 7 is a protein that in humans is encoded by the SLC12A7 gene.^[3][4]

See also

• Solute carrier family
• cotransporter

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Mount DB; Mercado A; Song L; Xu J; George AL Jr; Delpire E; Gamba G (Jul 1999). "Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family". J Biol Chem. 274 (23): 16355–62. doi:10.1074/jbc.274.23.16355. PMID 10347194.
4. "Entrez Gene: SLC12A7 solute carrier family 12 (potassium/chloride transporters), member 7".

Further reading

• Mercado A, Song L, Vazquez N, et al. (2000). "Functional comparison of the K⁺-Cl⁻ cotransporters KCC1 and KCC4". J. Biol. Chem. 275 (39): 30326–34. doi:10.1074/jbc.M003112200. PMID 10913127.
• Hattori A, Okumura K, Nagase T, et al. (2001). "Characterization of long cDNA clones from human adult spleen". DNA Res. 7 (6): 357–66. doi:10.1093/dnares/7.6.357. PMID 11214971.
• Boettger T, Hübner CA, Maier H, et al. (2002). "Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4". Nature. 416 (6883): 874–8. doi:10.1038/416874a. PMID 11976689.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bräuer M, Frei E, Claes L, et al. (2003). "Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl⁻ channels in human osteoblasts". Am. J. Physiol., Cell Physiol. 285 (1): C22–30. doi:10.1152/ajpcell.00289.2002. PMID 12637262.
• Karadsheh MF; Byun N; Mount DB; Delpire E (2004). "Localization of the KCC4 potassium-chloride cotransporter in the nervous system". Neuroscience. 123 (2): 381–91. doi:10.1016/j.neuroscience.2003.10.004. PMID 14698746.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Shen MR, Lin AC, Hsu YM, et al. (2004). "Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells". J. Biol. Chem. 279 (38): 40017–25. doi:10.1074/jbc.M406706200. PMID 15262997.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hsu YM, Chou CY, Chen HH, et al. (2007). "IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness". J. Cell. Physiol. 210 (3): 626–36. doi:10.1002/jcp.20859. PMID 17133354.