SLC41A3

SLC41A3
Identifiers
Aliases	SLC41A3, SLC41A1-L2, solute carrier family 41 member 3
External IDs	MGI: 1918949 HomoloGene: 23052 GeneCards: SLC41A3
Gene ontology Molecular function • cation transmembrane transporter activity • protein binding Cellular component • integral component of membrane • plasma membrane • membrane Biological process • cation transport • cation transmembrane transport • transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54946	71699
Ensembl	ENSG00000114544	ENSMUSG00000030089
UniProt	Q96GZ6	Q921R8
RefSeq (mRNA)	NM_001008485 NM_001008486 NM_001008487 NM_001164475 NM_017836	NM_001037493 NM_027868
RefSeq (protein)	NP_001008485.1 NP_001008486.1 NP_001008487.1 NP_001157947.1 NP_001008486.1	NP_001032570.1 NP_082144.2
Location (UCSC)	Chr 3: 126.01 – 126.1 Mb	Chr 6: 90.6 – 90.65 Mb
PubMed search	[1]	[2]
Wikidata

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Solute carrier family 41, member 3 is a protein that in humans is encoded by the SLC41A3 gene.^[3]

Model organisms

Slc41a3 knockout mouse phenotype

Characteristic	Phenotype
Homozygote viability	Normal
Fertility	Normal
Body weight	Normal
Anxiety	Normal
Neurological assessment	Abnormal
Grip strength	Normal
Hot plate	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Body temperature	Normal
Eye morphology	Normal
Clinical chemistry	Normal
Plasma immunoglobulins	Normal
Haematology	Normal
Micronucleus test	Normal
Heart weight	Normal
Tail epidermis wholemount	Normal
Skin Histopathology	Normal
Brain histopathology	Normal
Eye Histopathology	Normal
Salmonella infection	Normal[4]
Citrobacter infection	Normal[5]
All tests and analysis from[6][7]

Model organisms have been used in the study of SLC41A3 function. A conditional knockout mouse line, called Slc41a3^{tm1a(KOMP)Wtsi[8][9]} was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.^[10][11][12]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.^[6][13] Twenty six tests were carried out on mutant mice and one significant abnormality was observed: homozygous mutants displayed abnormal locomotor coordination.^[6]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: Solute carrier family 41, member 3". Retrieved 2011-09-28.
4. "Salmonella infection data for Slc41a3". Wellcome Trust Sanger Institute.
5. "Citrobacter infection data for Slc41a3". Wellcome Trust Sanger Institute.
6. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
7. Mouse Resources Portal, Wellcome Trust Sanger Institute.
8. "International Knockout Mouse Consortium".
9. "Mouse Genome Informatics".
10. Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
11. Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
12. Collins FS; Rossant J; Wurst W (2007). "A Mouse for All Reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
13. van der Weyden L; White JK; Adams DJ; Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading

• Wabakken, T.; Rian, E.; Kveine, M.; Aasheim, H. C. (2003). "The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters". Biochemical and Biophysical Research Communications. 306 (3): 718–724. doi:10.1016/S0006-291X(03)01030-1. PMID 12810078.