SLC30A3

SLC30A3
Identifiers
Aliases	SLC30A3, ZNT3, solute carrier family 30 member 3
External IDs	MGI: 1345280 HomoloGene: 74470 GeneCards: SLC30A3
Gene ontology Molecular function • zinc-transporting ATPase activity • protein binding • cation transmembrane transporter activity Cellular component • synapse • integral component of plasma membrane • late endosome membrane • lysosomal membrane • synaptic vesicle membrane • cytoplasm • endosome • cell junction • lysosome • synaptic vesicle • integral component of membrane • late endosome • membrane • cytoplasmic vesicle • neuron projection Biological process • response to zinc ion • ion transport • positive regulation of transport • cation transport • regulation of sequestering of zinc ion • cation transmembrane transport • zinc II ion transport • transport • zinc II ion transmembrane transport • transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7781	22784
Ensembl	ENSG00000115194	ENSMUSG00000029151
UniProt	Q99726	P97441
RefSeq (mRNA)	NM_003459 NM_001318949 NM_001318950 NM_001318951	NM_011773
RefSeq (protein)	NP_003450.2 NP_001305878.1 NP_001305879.1 NP_001305880.1	NP_035903.2
Location (UCSC)	Chr 2: 27.25 – 27.28 Mb	Chr 5: 31.09 – 31.11 Mb
PubMed search	[1]	[2]
Wikidata

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Zinc transporter 3 also known as solute carrier family 30 member 3 is a protein in humans that is encoded by the SLC30A3 gene.^[3]

The SLC30A3 gene codes for the ZnT-3 SLC30A family membrane transport protein. ZnT-3 is required for the accumulation of zinc ions inside synaptic vesicles.^[4] In mice, ZnT-3 is required for some forms of memory that depend on the hippocampus and the amygdala.^[5] Zinc transport by ZnT-3 modulates memory formation by acting through the extracellular signal-regulated kinases signaling pathway.^[6] Angiotensin II-induced senescence of vascular smooth muscle cells requires down-regulation of ZnT-3 and ZnT-10.^[7]

See also

• Solute carrier family

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: Solute carrier family 30 (zinc transporter), member 3".
4. Cole TB; Wenzel HJ; Kafer KE; Schwartzkroin PA; Palmiter RD (February 1999). "Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 gene". Proc. Natl. Acad. Sci. U.S.A. 96 (4): 1716–21. doi:10.1073/pnas.96.4.1716. PMC 15571. PMID 9990090.
5. Sindreu C; Storm DR (2011). "Modulation of neuronal signal transduction and memory formation by synaptic zinc". Front Behav Neurosci. 5: 68. doi:10.3389/fnbeh.2011.00068. PMC 3211062. PMID 22084630.
6. Mott DD; Dingledine R (February 2011). "Unraveling the role of zinc in memory". Proc. Natl. Acad. Sci. U.S.A. 108 (8): 3103–4. doi:10.1073/pnas.1100323108. PMC 3044369. PMID 21321213.
7. Patrushev N; Seidel-Rogol B; Salazar G (2012). "Angiotensin II requires zinc and downregulation of the zinc transporters ZnT3 and ZnT10 to induce senescence of vascular smooth muscle cells". PLoS ONE. 7 (3): e33211. doi:10.1371/journal.pone.0033211. PMC 3299759. PMID 22427991.