Salivary gland aplasia

Salivary gland aplasia (also termed salivary gland agenesis) is the congenital absence of salivary glands. Usually the term relates to the absence of some or all of the major salivary glands.

It is a rare condition, and most known cases have been in association with syndromes of the ectodermal tissues,^[1] particularly the lacrimal apparatus.^[2] Example syndromes which have been reported with salivary gland aplasia include hereditary ectodermal dysplasia, mandibulofacial dysostosis and hemifacial microsomia.^[3]

The main significance of the condition is a lack of saliva, causing xerostomia (dry mouth), with accompanying susceptibility to dental caries (tooth decay), infections of the mouth,^[1] and upper respiratory tract infections (e.g., candidiasis, ascending sialadenitis, laryngitis and pharyngitis).^[2] Patients with salivary gland aplasia typically require regular application of topical fluoride to prevent tooth decay.^[3]

References

1 2 Taji, SS; Savage, N; Holcombe, T; Khan, F; Seow, WK (2011). "Congenital aplasia of the major salivary glands: literature review and case report.". Pediatric dentistry. 33 (2): 113–8. PMID 21703060.
1 2 Kwon, SY; Jung, EJ; Kim, SH; Kim, TK (February 2006). "A case of major salivary gland agenesis.". Acta oto-laryngologica. 126 (2): 219–22. doi:10.1080/00016480500314139. PMID 16428204.
1 2 Purkait SK (2011). Essentials of Oral Pathology. JP Medical Ltd. p. 199. ISBN 978-93-5025-214-7.

Oral and maxillofacial pathology (K00–K06, K11–K14, 520–525, 527–529)

Lips

Cheilitis Actinic Angular Plasma cell Cleft lip Congenital lip pit Eclabium Herpes labialis Macrocheilia Microcheilia Nasolabial cyst Sun poisoning Trumpeter's wart

Tongue

Ankyloglossia Black hairy tongue Caviar tongue Crenated tongue Cunnilingus tongue Fissured tongue Foliate papillitis Glossitis Geographic tongue Median rhomboid glossitis Transient lingual papillitis Glossoptosis Hypoglossia Lingual thyroid Macroglossia Microglossia Rhabdomyoma

Palate

Bednar's aphthae Cleft palate High-arched palate Palatal cysts of the newborn Inflammatory papillary hyperplasia Stomatitis nicotina Torus palatinus

Oral mucosa - Lining of mouth

Teeth (pulp, dentin, enamel)

Periodontium (gingiva, periodontal ligament, cementum, alveolus) - Gums and tooth-supporting structures

Periapaical, mandibular and maxillary hard tissues - Bones of jaws

Temporomandibular joints, muscles of mastication and malocclusions - Jaw joints, chewing muscles and bite abnormalities

Bruxism Condylar resorption Mandibular dislocation Malocclusion Crossbite Open bite Overbite Overjet Prognathia Retrognathia Temporomandibular joint dysfunction

Salivary glands

Orofacial soft tissues - Soft tissues around the mouth

Actinomycosis Angioedema Basal cell carcinoma Cutaneous sinus of dental origin Cystic hygroma Gnathophyma Ludwig's angina Macrostomia Melkersson–Rosenthal syndrome Microstomia Noma Oral Crohn's disease Orofacial granulomatosis Perioral dermatitis Pyostomatitis vegetans

Other

Eagle syndrome Hemifacial hypertrophy Facial hemiatrophy Oral manifestations of systemic disease

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