8-Phenyltheophylline

8-Phenyltheophylline

Identifiers
IUPAC name 8-phenyl-1,3-dimethyl-7H-purine-2,6-dione
CAS Number	961-45-5
PubChem (CID)	1922
ChemSpider	1846
ChEMBL	CHEMBL62350
Chemical and physical data
Formula	C13H12N4O2
Molar mass	256.259 g/mol
3D model (Jmol)	Interactive image
SMILES c3ccccc3-c(nc12)nc2n(C)c(=O)n(C)c1=O
InChI InChI=1S/C13H12N4O2/c1-16-11-9(12(18)17(2)13(16)19)14-10(15-11)8-6-4-3-5-7-8/h3-7H,1-2H3,(H,14,15) Key:PJFMAVHETLRJHJ-UHFFFAOYSA-N
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8-Phenyltheophylline (8-Phenyl-1,3-dimethylxanthine, 8-PT) is a drug derived from the xanthine family which acts as a potent and selective antagonist for the adenosine receptors A₁ and A_2A, but unlike other xanthine derivatives has virtually no activity as a phosphodiesterase inhibitor.^[1][2][3] It has stimulant effects in animals with similar potency to caffeine.^[4] Coincidentally 8-phenyltheophylline has also been found to be a potent and selective inhibitor of the liver enzyme CYP1A2 which makes it likely to cause interactions with other drugs which are normally metabolised by CYP1A2.^[5]

See also

• 8-Chlorotheophylline
• 8-Cyclopentyltheophylline
• DPCPX
• DMPX
• Xanthine

References

1. Scotini E; Carpenedo F; Fassina G (February 1983). "New derivatives of methyl-xanthines: effect of thiocaffeine thiotheophylline and 8-phenyltheophylline on lipolysis and on phosphodiesterase activities". Pharmacological Research Communications. 15 (2): 131–43. doi:10.1016/s0031-6989(83)80055-1. PMID 6844374.
2. Rabe KF; Magnussen H; Dent G (April 1995). "Theophylline and selective PDE inhibitors as bronchodilators and smooth muscle relaxants". European Respiratory Journal. 8 (4): 637–42. PMID 7664866.
3. Howell LL; Morse WH; Spealman RD (September 1990). "Respiratory effects of xanthines and adenosine analogs in rhesus monkeys". The Journal of Pharmacology and Experimental Therapeutics. 254 (3): 786–91. PMID 2395111.
4. Spealman RD (1988). "Psychomotor stimulant effects of methylxanthines in squirrel monkeys: relation to adenosine antagonism". Psychopharmacology. 95 (1): 19–24. doi:10.1007/bf00212759. PMID 3133696.
5. Murray S; Odupitan AO; Murray BP; Boobis AR; Edwards RJ (March 2001). "Inhibition of human CYP1A2 activity in vitro by methylxanthines: potent competitive inhibition by 8-phenyltheophylline". Xenobiotica. 31 (3): 135–51. doi:10.1080/00498250110043292. PMID 11465391.