CLTC

CLTC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XZG, 4G55
Identifiers
Aliases	CLTC, CHC, CHC17, CLH-17, CLTCL2, Hc, clathrin heavy chain
External IDs	MGI: 2388633 HomoloGene: 3572 GeneCards: CLTC
Gene ontology Molecular function • clathrin light chain binding • protein binding • double-stranded RNA binding • poly(A) RNA binding • protein kinase binding • structural molecule activity Cellular component • extracellular vesicle • cytosol • clathrin-coated endocytic vesicle membrane • clathrin coat of coated pit • trans-Golgi network membrane • intracellular membrane-bounded organelle • clathrin coat of trans-Golgi network vesicle • focal adhesion • clathrin coat • melanosome • plasma membrane • spindle • protein complex • clathrin complex • endolysosome membrane • clathrin-coated pit • extracellular exosome • cytoplasmic vesicle membrane • cytoplasmic vesicle • clathrin-coated vesicle • extracellular matrix • membrane • mitotic spindle microtubule • intracellular Biological process • mitotic nuclear division • antigen processing and presentation of exogenous peptide antigen via MHC class II • transferrin transport • receptor internalization • receptor-mediated endocytosis • negative regulation of protein localization to plasma membrane • retrograde transport, endosome to Golgi • osteoblast differentiation • vesicle-mediated transport • negative regulation of hyaluronan biosynthetic process • intracellular protein transport • Wnt signaling pathway, planar cell polarity pathway • regulation of mitotic spindle organization Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1213	67300
Ensembl	ENSG00000141367	ENSMUSG00000047126
UniProt	Q00610	Q68FD5
RefSeq (mRNA)	NM_001288653 NM_004859	NM_001003908
RefSeq (protein)	NP_004850.1	NP_001003908.1
Location (UCSC)	Chr 17: 59.62 – 59.7 Mb	Chr 11: 86.69 – 86.76 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Clathrin heavy chain 1 is a protein that in humans is encoded by the CLTC gene.^[3][4]

Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains.^[5]

Interactions

CLTC has been shown to interact with PICALM^[6] and HGS.^[7]

See also

• Clathrin

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Dodge GR, Kovalszky I, McBride OW, Yi HF, Chu ML, Saitta B, Stokes DG, Iozzo RV (Feb 1992). "Human clathrin heavy chain (CLTC): partial molecular cloning, expression, and mapping of the gene to human chromosome 17q11-qter". Genomics. 11 (1): 174–8. doi:10.1016/0888-7543(91)90115-U. PMID 1765375.
4. Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
5. "Entrez Gene: CLTC clathrin, heavy chain (Hc)".
6. Tebar, F; Bohlander S K; Sorkin A (Aug 1999). "Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic". Mol. Biol. Cell. UNITED STATES. 10 (8): 2687–702. doi:10.1091/mbc.10.8.2687. ISSN 1059-1524. PMC 25500. PMID 10436022.
7. Raiborg, C; Bache K G; Mehlum A; Stang E; Stenmark H (Sep 2001). "Hrs recruits clathrin to early endosomes". EMBO J. England. 20 (17): 5008–21. doi:10.1093/emboj/20.17.5008. ISSN 0261-4189. PMC 125612. PMID 11532964.

Further reading

• Murphy JE, Keen JH (1992). "Recognition sites for clathrin-associated proteins AP-2 and AP-3 on clathrin triskelia.". J. Biol. Chem. 267 (15): 10850–5. PMID 1587861.
• Corvera S (1990). "Insulin stimulates the assembly of cytosolic clathrin onto adipocyte plasma membranes.". J. Biol. Chem. 265 (5): 2413–6. PMID 2154445.
• Scarmato P, Kirchhausen T (1990). "Analysis of clathrin light chain-heavy chain interactions using truncated mutants of rat liver light chain LCB3.". J. Biol. Chem. 265 (7): 3661–8. PMID 2406259.
• Hanspal M, Luna E, Branton D (1984). "The association of clathrin fragments with coated vesicle membranes.". J. Biol. Chem. 259 (17): 11075–82. PMID 6147350.
• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement).". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
• Fausser JL, Ungewickell E, Ruch JV, Lesot H (1994). "Interaction of vinculin with the clathrin heavy chain.". J. Biochem. 114 (4): 498–503. PMID 8276759.
• Kedra D, Peyrard M, Fransson I, et al. (1997). "Characterization of a second human clathrin heavy chain polypeptide gene (CLH-22) from chromosome 22q11.". Hum. Mol. Genet. 5 (5): 625–31. doi:10.1093/hmg/5.5.625. PMID 8733129.
• Goodman OB, Krupnick JG, Gurevich VV, et al. (1997). "Arrestin/clathrin interaction. Localization of the arrestin binding locus to the clathrin terminal domain.". J. Biol. Chem. 272 (23): 15017–22. doi:10.1074/jbc.272.23.15017. PMID 9169477.
• Ramjaun AR, Micheva KD, Bouchelet I, McPherson PS (1997). "Identification and characterization of a nerve terminal-enriched amphiphysin isoform.". J. Biol. Chem. 272 (26): 16700–6. doi:10.1074/jbc.272.26.16700. PMID 9195986.
• McMahon HT, Wigge P, Smith C (1997). "Clathrin interacts specifically with amphiphysin and is displaced by dynamin.". FEBS Lett. 413 (2): 319–22. doi:10.1016/S0014-5793(97)00928-9. PMID 9280305.
• Foti M, Mangasarian A, Piguet V, et al. (1998). "Nef-mediated clathrin-coated pit formation.". J. Cell Biol. 139 (1): 37–47. doi:10.1083/jcb.139.1.37. PMC 2139808. PMID 9314527.
• Dell'Angelica EC, Klumperman J, Stoorvogel W, Bonifacino JS (1998). "Association of the AP-3 adaptor complex with clathrin.". Science. 280 (5362): 431–4. doi:10.1126/science.280.5362.431. PMID 9545220.
• Ramjaun AR, McPherson PS (1998). "Multiple amphiphysin II splice variants display differential clathrin binding: identification of two distinct clathrin-binding sites.". J. Neurochem. 70 (6): 2369–76. doi:10.1046/j.1471-4159.1998.70062369.x. PMID 9603201.
• ter Haar E, Musacchio A, Harrison SC, Kirchhausen T (1998). "Atomic structure of clathrin: a beta propeller terminal domain joins an alpha zigzag linker.". Cell. 95 (4): 563–73. doi:10.1016/S0092-8674(00)81623-2. PMID 9827808.
• Laporte SA, Oakley RH, Zhang J, et al. (1999). "The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis.". Proc. Natl. Acad. Sci. U.S.A. 96 (7): 3712–7. doi:10.1073/pnas.96.7.3712. PMC 22359. PMID 10097102.
• Turner CE, Brown MC, Perrotta JA, et al. (1999). "Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling.". J. Cell Biol. 145 (4): 851–63. doi:10.1083/jcb.145.4.851. PMC 2133183. PMID 10330411.
• Hussain NK, Yamabhai M, Ramjaun AR, et al. (1999). "Splice variants of intersectin are components of the endocytic machinery in neurons and nonneuronal cells.". J. Biol. Chem. 274 (22): 15671–7. doi:10.1074/jbc.274.22.15671. PMID 10336464.
• Ybe JA, Brodsky FM, Hofmann K, et al. (1999). "Clathrin self-assembly is mediated by a tandemly repeated superhelix.". Nature. 399 (6734): 371–5. doi:10.1038/20708. PMID 10360576.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.