COPB1

COPB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5A1U, 5A1V, 5A1W, 5A1X, 5A1Y
Identifiers
Aliases	COPB1, COPB, coatomer protein complex subunit beta 1
External IDs	MGI: 1917599 HomoloGene: 5664 GeneCards: COPB1
Gene ontology Molecular function • structural molecule activity • protein binding Cellular component • cytoplasm • cytosol • Golgi apparatus • membrane • intracellular membrane-bounded organelle • Golgi membrane • plasma membrane • COPI-coated vesicle membrane • transport vesicle • Golgi-associated vesicle • membrane coat • COPI vesicle coat • cytoplasmic vesicle • COPI-coated vesicle • endoplasmic reticulum-Golgi intermediate compartment • endoplasmic reticulum membrane Biological process • retrograde vesicle-mediated transport, Golgi to ER • ER to Golgi vesicle-mediated transport • transport • protein transport • intracellular protein transport • viral process • intra-Golgi vesicle-mediated transport • vesicle-mediated transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1315	70349
Ensembl	ENSG00000129083	ENSMUSG00000030754
UniProt	P53618	Q9JIF7
RefSeq (mRNA)	NM_016451 NM_001144061 NM_001144062	NM_033370
RefSeq (protein)	NP_001137533.1 NP_001137534.1 NP_057535.1	NP_203534.1
Location (UCSC)	Chr 11: 14.44 – 14.5 Mb	Chr 7: 114.22 – 114.25 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Coatomer subunit beta is a protein that in humans is encoded by the COPB1 gene.^[3]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Benichou S, Bomsel M, Bodeus M, Durand H, Doute M, Letourneur F, Camonis J, Benarous R (Dec 1994). "Physical interaction of the HIV-1 Nef protein with beta-COP, a component of non-clathrin-coated vesicles essential for membrane traffic". J Biol Chem. 269 (48): 30073–6. PMID 7982906.

Further reading

• Benichou S, Liu LX, Erdtmann L, et al. (1997). "Use of the two-hybrid system to identify cellular partners of the HIV1 Nef protein". Res. Virol. 148 (1): 71–3. doi:10.1016/S0923-2516(97)81918-8. PMID 9017839.
• Geyer M, Fackler OT, Peterlin BM (2001). "Structure–function relationships in HIV-1 Nef". EMBO Rep. 2 (7): 580–5. doi:10.1093/embo-reports/kve141. PMC 1083955. PMID 11463741.
• Duden R, Griffiths G, Frank R, et al. (1991). "Beta-COP, a 110 kd protein associated with non-clathrin-coated vesicles and the Golgi complex, shows homology to beta-adaptin". Cell. 64 (3): 649–65. doi:10.1016/0092-8674(91)90248-W. PMID 1840503.
• Waters MG, Serafini T, Rothman JE (1991). "'Coatomer': a cytosolic protein complex containing subunits of non-clathrin-coated Golgi transport vesicles". Nature. 349 (6306): 248–51. doi:10.1038/349248a0. PMID 1898986.
• Orcl L, Palmer DJ, Amherdt M, Rothman JE (1993). "Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins from the cytosol". Nature. 364 (6439): 732–4. doi:10.1038/364732a0. PMID 8355790.
• Aniento F, Gu F, Parton RG, Gruenberg J (1996). "An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes". J. Cell Biol. 133 (1): 29–41. doi:10.1083/jcb.133.1.29. PMC 2120778. PMID 8601610.
• Lowe M, Kreis TE (1997). "In vivo assembly of coatomer, the COP-I coat precursor". J. Biol. Chem. 271 (48): 30725–30. doi:10.1074/jbc.271.48.30725. PMID 8940050.
• Hansen K, Rönnstrand L, Rorsman C, et al. (1997). "Association of coatomer proteins with the beta-receptor for platelet-derived growth factor". Biochem. Biophys. Res. Commun. 235 (3): 455–60. doi:10.1006/bbrc.1997.6821. PMID 9207175.
• Pavel J, Harter C, Wieland FT (1998). "Reversible dissociation of coatomer: Functional characterization of a β/δ-coat protein subcomplex". Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2140–5. doi:10.1073/pnas.95.5.2140. PMC 19276. PMID 9482852.
• Piguet V, Gu F, Foti M, et al. (1999). "Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes". Cell. 97 (1): 63–73. doi:10.1016/S0092-8674(00)80715-1. PMID 10199403.
• Zhao L, Helms JB, Brunner J, Wieland FT (1999). "GTP-dependent binding of ADP-ribosylation factor to coatomer in close proximity to the binding site for dilysine retrieval motifs and p23". J. Biol. Chem. 274 (20): 14198–203. doi:10.1074/jbc.274.20.14198. PMID 10318838.
• Fischer KD, Helms JB, Zhao L, Wieland FT (2000). "Site-specific photocrosslinking to probe interactions of Arf1 with proteins involved in budding of COPI vesicles". Methods. 20 (4): 455–64. doi:10.1006/meth.2000.0958. PMID 10720466.
• Allan BB, Moyer BD, Balch WE (2000). "Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion". Science. 289 (5478): 444–8. doi:10.1126/science.289.5478.444. PMID 10903204.
• Eugster A, Frigerio G, Dale M, Duden R (2000). "COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP". EMBO J. 19 (15): 3905–17. doi:10.1093/emboj/19.15.3905. PMC 306616. PMID 10921873.
• Sullivan BM, Harrison-Lavoie KJ, Marshansky V, et al. (2000). "RGS4 and RGS2 Bind Coatomer and Inhibit COPI Association with Golgi Membranes and Intracellular Transport". Mol. Biol. Cell. 11 (9): 3155–68. doi:10.1091/mbc.11.9.3155. PMC 14982. PMID 10982407.
• Futatsumori M, Kasai K, Takatsu H, et al. (2001). "Identification and characterization of novel isoforms of COP I subunits". J. Biochem. 128 (5): 793–801. doi:10.1093/oxfordjournals.jbchem.a022817. PMID 11056392.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.