SYT11

SYT11
Identifiers
Aliases	SYT11, SYT12, sytXI, synaptotagmin 11
External IDs	MGI: 1859547 HomoloGene: 23120 GeneCards: SYT11
Gene ontology Molecular function • calcium-dependent phospholipid binding • clathrin binding • calcium ion binding • syntaxin binding • protein binding • metal ion binding • translation initiation factor binding • ubiquitin protein ligase binding • SNARE binding • protein homodimerization activity • beta-tubulin binding Cellular component • integral component of membrane • cell junction • synapse • integral component of plasma membrane • synaptic vesicle membrane • membrane • cytoplasmic vesicle • vesicle • phagocytic cup • presynaptic active zone membrane • inhibitory synapse • synaptic vesicle • presynapse • dendritic spine • lysosome • cytoplasm • recycling endosome • postsynaptic density • plasma membrane • cell body • phagocytic vesicle • axon • early phagosome • excitatory synapse Biological process • negative regulation of neurotransmitter secretion • regulation of phagosome maturation • negative regulation of interleukin-6 secretion • plasma membrane repair • regulation of defense response to bacterium • negative regulation of tumor necrosis factor secretion • regulation of calcium ion-dependent exocytosis • calcium ion-regulated exocytosis of neurotransmitter • negative regulation of synaptic vesicle endocytosis • negative regulation of membrane invagination • vesicle fusion • protein homotetramerization • negative regulation of clathrin-dependent endocytosis • negative regulation of phagocytosis • calcium ion regulated lysosome exocytosis • positive regulation of protein localization to phagocytic vesicle Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23208	229521
Ensembl	ENSG00000132718	ENSMUSG00000068923
UniProt	Q9BT88	Q9R0N3
RefSeq (mRNA)	NM_152280	NM_018804
RefSeq (protein)	NP_689493.3	NP_061274.2
Location (UCSC)	Chr 1: 155.86 – 155.89 Mb	Chr 3: 88.74 – 88.78 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Synaptotagmin-11 is a protein that in humans is encoded by the SYT11 gene.^[3][4]

Interactions

SYT11 has been shown to interact with Parkin (ligase).^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Craxton M (September 2001). "Genomic analysis of synaptotagmin genes". Genomics. 77 (1-2): 43–9. doi:10.1006/geno.2001.6619. PMID 11543631.
4. "Entrez Gene: SYT11 synaptotagmin XI".
5. Huynh DP, Scoles DR, Nguyen D, Pulst SM (October 2003). "The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI". Human Molecular Genetics. 12 (20): 2587–97. doi:10.1093/hmg/ddg269. PMID 12925569.

Further reading

• Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
• Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (March 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
• Huynh DP, Scoles DR, Nguyen D, Pulst SM (October 2003). "The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI". Human Molecular Genetics. 12 (20): 2587–97. doi:10.1093/hmg/ddg269. PMID 12925569.
• Glass AS, Huynh DP, Franck T, Woitalla D, Müller T, Pulst SM, Berg D, Krüger R, Riess O (2004). "Screening for mutations in synaptotagmin XI in Parkinson's disease". Journal of Neural Transmission. Supplementum (68): 21–8. PMID 15354386.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Inoue S, Imamura A, Okazaki Y, Yokota H, Arai M, Hayashi N, Furukawa A, Itokawa M, Oishi M (April 2007). "Synaptotagmin XI as a candidate gene for susceptibility to schizophrenia". American Journal of Medical Genetics Part B. 144B (3): 332–40. doi:10.1002/ajmg.b.30465. PMID 17192956.