SYT9

SYT9
Identifiers
Aliases	SYT9
External IDs	MGI: 1926373 HomoloGene: 11062 GeneCards: SYT9
Gene ontology Molecular function • calcium-dependent phospholipid binding • metal ion binding • clathrin binding • calcium ion binding • syntaxin binding • identical protein binding • phosphatidylserine binding • phosphatidylinositol-4,5-bisphosphate binding • SNARE binding Cellular component • cytoplasmic vesicle • integral component of membrane • cell junction • synapse • dense core granule • synaptic vesicle membrane • exocytic vesicle • secretory granule membrane • membrane • secretory granule • plasma membrane Biological process • regulation of insulin secretion • positive regulation of calcium ion-dependent exocytosis • regulation of calcium ion-dependent exocytosis • vesicle fusion • calcium ion-regulated exocytosis of neurotransmitter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	143425	60510
Ensembl	ENSG00000170743	ENSMUSG00000062542
UniProt	Q86SS6	Q9R0N9
RefSeq (mRNA)	NM_175733	NM_021889
RefSeq (protein)	NP_783860.1	NP_068689.2
Location (UCSC)	Chr 11: 7.24 – 7.47 Mb	Chr 7: 107.37 – 107.55 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Synaptotagmin-9 is a protein that in humans is encoded by the SYT9 gene.^[3][4]

Interactions

SYT9 has been shown to interact with SYNCRIP,^[5] TUBB^[6] and TRPV1.^[7]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Craxton M (Sep 2001). "Genomic analysis of synaptotagmin genes". Genomics. 77 (1-2): 43–9. doi:10.1006/geno.2001.6619. PMID 11543631.
4. "Entrez Gene: SYT9 synaptotagmin IX".
5. Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (Mar 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
6. Haberman Y, Grimberg E, Fukuda M, Sagi-Eisenberg R (Nov 2003). "Synaptotagmin IX, a possible linker between the perinuclear endocytic recycling compartment and the microtubules". Journal of Cell Science. 116 (Pt 21): 4307–18. doi:10.1242/jcs.00719. PMID 12966166.
7. Morenilla-Palao C, Planells-Cases R, García-Sanz N, Ferrer-Montiel A (Jun 2004). "Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity". The Journal of Biological Chemistry. 279 (24): 25665–72. doi:10.1074/jbc.M311515200. PMID 15066994.

Further reading

• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Morenilla-Palao C, Planells-Cases R, García-Sanz N, Ferrer-Montiel A (Jun 2004). "Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity". The Journal of Biological Chemistry. 279 (24): 25665–72. doi:10.1074/jbc.M311515200. PMID 15066994.
• Haberman Y, Grimberg E, Fukuda M, Sagi-Eisenberg R (Nov 2003). "Synaptotagmin IX, a possible linker between the perinuclear endocytic recycling compartment and the microtubules". Journal of Cell Science. 116 (Pt 21): 4307–18. doi:10.1242/jcs.00719. PMID 12966166.

\* Dubois T, Howell S, Zemlickova E, Aitken A (Apr 2002). "Identification of casein kinase Ialpha interacting protein partners". FEBS Letters. 517 (1-3): 167–71. doi:10.1016/S0014-5793(02)02614-5. PMID 12062430.

• Zhang X, Kim-Miller MJ, Fukuda M, Kowalchyk JA, Martin TF (May 2002). "Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for Ca2+-triggered exocytosis". Neuron. 34 (4): 599–611. doi:10.1016/S0896-6273(02)00671-2. PMID 12062043.
• Fukuda M, Kowalchyk JA, Zhang X, Martin TF, Mikoshiba K (Feb 2002). "Synaptotagmin IX regulates Ca2+-dependent secretion in PC12 cells". The Journal of Biological Chemistry. 277 (7): 4601–4. doi:10.1074/jbc.C100588200. PMID 11751925.
• Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (Mar 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
• Perin MS (Oct 1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin". Biochemistry. 35 (43): 13808–16. doi:10.1021/bi960853x. PMID 8901523.