DCPG

DCPG

Identifiers
IUPAC name 4-[(1S)-1-amino-2-hydroxy-2-oxoethyl]phthalic acid
CAS Number	201730-11-2
PubChem (CID)	16062593
IUPHAR/BPS	1407
ChemSpider	17222214
ECHA InfoCard	100.161.870
Chemical and physical data
Formula	C10H9NO6
Molar mass	239.181 g/mol
3D model (Jmol)	Interactive image
SMILES O=C(O)[C@@H](N)c1cc(c(C(=O)O)cc1)C(=O)O
InChI InChI=1S/C10H9NO6/c11-7(10(16)17)4-1-2-5(8(12)13)6(3-4)9(14)15/h1-3,7H,11H2,(H,12,13)(H,14,15)(H,16,17)/t7-/m0/s1 Key:IJVMOGKBEVRBPP-ZETCQYMHSA-N
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DCPG ((S)-3,4-DCPG) is a drug used in scientific research, which acts as a potent and subtype-selective agonist for the metabotropic glutamate receptor mGluR₈. It has anticonvulsant effects in animal studies,^[1][2] and has also been investigated as a possible treatment for hyperalgesia.^[3]

References

1. Moldrich RX, Chapman AG, De Sarro G, Meldrum BS. Glutamate metabotropic receptors as targets for drug therapy in epilepsy. European Journal of Pharmacology. 2003 Aug 22;476(1-2):3-16. doi:10.1016/S0014-2999(03)02149-6 PMID 12969743
2. Folbergrová J, Druga R, Haugvicová R, Mares P, Otáhal J. Anticonvulsant and neuroprotective effect of (S)-3,4-dicarboxyphenylglycine against seizures induced in immature rats by homocysteic acid. Neuropharmacology. 2008 Mar;54(4):665-75. PMID 18191956
3. Marabese I, de Novellis V, Palazzo E, Scafuro MA, Vita D, Rossi F, Maione S. Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice. Neuropharmacology. 2007 Feb;52(2):253-62. PMID 17113112