ADX-71149

ADX-71149
Clinical data

ATC code	None
Identifiers
IUPAC name 1-Butyl-3-chloro-4-(4-phenylpiperidin-1-yl)-1,2-dihydropyridin-2-one
CAS Number	1127498-03-6
PubChem (CID)	25195461
IUPHAR/BPS	8946
ChemSpider	28424210
UNII	612BYT76F3^Y
ChEMBL	CHEMBL3337527
Chemical and physical data
Formula	C₂₀H₂₅ClN₂O
Molar mass	344.88 g·mol⁻¹
3D model (Jmol)	Interactive image
SMILES CCCCN1C=CC(=C(C1=O)Cl)N2CCC(CC2)C3=CC=CC=C3
InChI InChI=1S/C20H25ClN2O/c1-2-3-12-23-15-11-18(19(21)20(23)24)22-13-9-17(10-14-22)16-7-5-4-6-8-16/h4-8,11,15,17H,2-3,9-10,12-14H2,1H3 Key:HYOGJHCDLQSAHX-UHFFFAOYSA-N

ADX-71149, also known as JNJ-40411813 and JNJ-mGluR2-PAM, is a selective positive allosteric modulator of the mGlu₂ receptor.^[1]^[2]^[3] It is being studied by Addex Therapeutics and Janssen Pharmaceuticals for the treatment of schizophrenia.^[4] It was also researched by these companies for the treatment of anxious depression (major depressive disorder with anxiety symptoms),^[5] but although some efficacy was observed in clinical trials, it was not enough to warrant further development for this indication.^[6] As of 2015, ADX-71149 is in phase II clinical trials for schizophrenia.^[4]

References

↑ Cid, José María; Tresadern, Gary; Duvey, Guillaume; Lütjens, Robert; Finn, Terry; Rocher, Jean-Philippe; Poli, Sonia; Vega, Juan Antonio; de Lucas, Ana Isabel; Matesanz, Encarnación; Linares, María Lourdes; Andrés, José Ignacio; Alcazar, Jesús; Alonso, José Manuel; Macdonald, Gregor J.; Oehlrich, Daniel; Lavreysen, Hilde; Ahnaou, Abdelah; Drinkenburg, Wilhelmus; Mackie, Claire; Pype, Stefan; Gallacher, David; Trabanco, Andrés A. (2014). "Discovery of 1-Butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): A Novel Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor". Journal of Medicinal Chemistry. 57 (15): 6495–512. doi:10.1021/jm500496m. PMID 25032784.
↑ Lavreysen, Hilde; Ahnaou, Abdellah; Drinkenburg, Wilhelmus; Langlois, Xavier; Mackie, Claire; Pype, Stefan; Lütjens, Robert; Le Poul, Emmanuel; Trabanco, Andrés A.; Nuñez, José María Cid (2015). "Pharmacological and pharmacokinetic properties of JNJ-40411813, a positive allosteric modulator of the mGlu2 receptor". Pharmacology Research & Perspectives. 3 (1): e00096. doi:10.1002/prp2.96. PMC 4317228. PMID 25692015.
↑ Lavreysen, Hilde; Langlois, Xavier; Donck, Luc Ver; Nuñez, José María Cid; Pype, Stefan; Lütjens, Robert; Megens, Anton (2015). "Preclinical evaluation of the antipsychotic potential of the mGlu2-positive allosteric modulator JNJ-40411813". Pharmacology Research & Perspectives. 3 (2): e00097. doi:10.1002/prp2.97. PMC 4324682. PMID 25692027.
1 2 Walker, Adam G; Conn, P Jeffrey (2015). "Group I and group II metabotropic glutamate receptor allosteric modulators as novel potential antipsychotics". Current Opinion in Pharmacology. 20: 40–5. doi:10.1016/j.coph.2014.11.003. PMC 4318747. PMID 25462291.
↑ Dunlop, John; Brandon, Nicholas J (2015). "Schizophrenia drug discovery and development in an evolving era: Are new drug targets fulfilling expectations?". Journal of Psychopharmacology. 29 (2): 230–8. doi:10.1177/0269881114565806. PMID 25586401.
↑ Addex Therapeutics (7 February 2014). "Addex Reports Top-line Data from ADX71149 Phase 2a Study in Patients with Major Depressive Disorder (MDD) with Significant Anxiety Symptoms". Retrieved 24 May 2015.

External links

Glutamatergics

Receptor
(ligands)

AMPA	Agonists: Glutamate/active site agonists: 5-Fluorowillardiine Acromelic acid (acromelate) AMPA BOAA Domoic acid Glutamate Ibotenic acid Proline Quisqualic acid Willardiine; Positive allosteric modulators: Aniracetam Cyclothiazide CX-516 CX-546 CX-614 Farampator (CX-691, Org 24448) CX-717 CX-1739 CX-1942 Diazoxide Hydrochlorothiazide (HCTZ) IDRA-21 LY-392,098 LY-404,187 LY-451,646 LY-503,430 Mibampator (LY-451,395) Org 26576 Oxiracetam PEPA PF-04958242 Piracetam Pramiracetam S-18986 Sunifiram Unifiram Antagonists: ACEA-1011 ATPO Becampanel Caroverine CNQX Dasolampanel DNQX Fanapanel (MPQX) GAMS GYKI-52466 Kynurenic acid Kynurenine Licostinel (ACEA-1021) NBQX PNQX Selurampanel Tezampanel Theanine Topiramate YM90K Zonampanel; Negative allosteric modulators: Barbiturates (e.g., pentobarbital, sodium thiopental) Cyclopropane Enflurane Ethanol Evans blue GYKI-53,655 Halothane Irampanel Isoflurane Perampanel Pregnenolone sulfate Talampanel

NMDA	Agonists: Glutamate/active site agonists: AMAA Aspartate Glutamate Homocysteic acid (L-HCA) Homoquinolinic acid Ibotenic acid NMDA Proline Quinolinic acid Tetrazolylglycine Theanine; Glycine site agonists: β-Fluoro-D-alanine ACBD ACC (ACPC) ACPD AK-51 Apimostinel (NRX-1074) B6B21 CCG D-Alanine D-Cycloserine D-Serine DHPG Dimethylglycine Glycine HA-966 L-687,414 L-Alanine L-Serine Milacemide Neboglamine (nebostinel) Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEA DHEA sulfate Pregnenolone sulfate SAGE-718 Antagonists: Competitive antagonists: AP5 (APV) AP7 CGP-37849 CGP-39551 CGP-39653 CGP-40116 CGS-19755 CPP LY-233,053 LY-235,959 LY-274,614 MDL-100,453 Midafotel (d-CPPene) NPC-12,626 NPC-17,742 PBPD PEAQX Perzinfotel PPDA SDZ-220581 Selfotel; Noncompetitive antagonists: ARR-15,896 Caroverine Dexanabinol FPL-12495 FR-115,427 Hodgkinsine Magnesium MDL-27,266 NPS-1506 Psychotridine Zinc; Uncompetitive pore blockers: 2-MDP 3-HO-PCP 3-MeO-PCE 3-MeO-PCMo 3-MeO-PCP 4-MeO-PCP 8A-PDHQ 18-MC α-Endopsychosin Alaproclate Amantadine Aptiganel Arketamine ARL-12,495 ARL-15,896-AR ARL-16,247 Budipine Conaridine Delucemine Dexoxadrol Dextrallorphan Dieticyclidine Diphenidine Dizocilpine Ephenidine Esketamine Etoxadrol Eticyclidine Fluorolintane Gacyclidine Ibogaine Ibogamine Indantadol Ketamine Ketobemidone Lanicemine Loperamide Memantine Methadone (Levomethadone) Methorphan (Dextromethorphan Levomethorphan) Methoxetamine Methoxphenidine Milnacipran Morphanol (Dextrorphan Levorphanol) NEFA Neramexane Nitromemantine Nitrous oxide Noribogaine Norketamine Orphenadrine PCPr Pethidine (meperidine) Phencyclamine Phencyclidine Propoxyphene Remacemide Rhynchophylline Rimantadine Rolicyclidine Sabeluzole Tabernanthine Tenocyclidine Tiletamine Tramadol Xenon; Glycine site antagonists: 4-Cl-KYN (AV-101) 5,7-DCKA 7-CKA ACC ACEA-1011 ACEA-1328 AV-101 Carisoprodol CGP-39653 CNQX DNQX Felbamate Gavestinel GV-196,771 Kynurenic acid Kynurenine L-689,560 L-701,324 Licostinel (ACEA-1021) LU-73,068 MDL-105,519 Meprobamate MRZ 2/576 PNQX ZD-9379; NR2B subunit antagonists: Besonprodil CERC-301 (MK-0657) CO-101,244 (PD-174,494) Eliprodil Haloperidol Ifenprodil Isoxsuprine Nylidrin Ro8-4304 Ro25-6981 Traxoprodil; Polyamine site antagonists: Arcaine Co 101676 Diaminopropane Diethylenetriamine Huperzine A Putrescine Ro 25-6981; Unclassified/unsorted antagonists: Bumetanide Chloroform Cyclopropane D-αAA Diethyl ether Enflurane Ethanol Flufenamic acid Flupirtine Furosemide Halothane Isoflurane Metaphit Methoxyflurane Niflumic acid Pentamidine isethionate Piretanide Toluene Transcrocetin (saffron) Trichloroethane Trichloroethanol Trichloroethylene Xylene

Kainate	Agonists: Glutamate/active site agonists: 5-Bromowillardiine 5-Iodowillardiine Acromelic acid (acromelate) AMPA ATPA Domoic acid Glutamate Ibotenic acid Kainic acid LY-339,434 Proline Quisqualic acid SYM-2081; Positive allosteric modulators: Cyclothiazide Diazoxide Enflurane Halothane Isoflurane Antagonists: ACEA-1011 CNQX Dasolampanel DNQX GAMS Kynurenic acid Licostinel (ACEA-1021) LY-382,884 NBQX NS102 Selurampanel Tezampanel Theanine Topiramate UBP-302; Negative allosteric modulators: Barbiturates (e.g., pentobarbital, sodium thiopental) Enflurane Ethanol Evans blue NS-3763 Pregnenolone sulfate

mGlu₁	Agonists: ACPD DHPG Glutamate Ibotenic acid Quisqualic acid Ro01-6128 Ro67-4853 Ro67-7476 VU-71 Antagonists: BAY 36-7620 CPCCOEt Cyclothiazide LY-367,385 LY-456,236 MCPG NPS-2390

mGlu₂	Agonists: BINA CBiPES DCG-IV Eglumegad Glutamate Ibotenic acid LY-379,268 LY-404,039 (pomaglumetad) LY-487,379 LY-566,332 MGS-0028 Pomaglumetad methionil (LY-2140023) Talaglumetad; Positive allosteric modulators: JNJ-40411813 (ADX-71149) Antagonists: APICA CECXG EGLU HYDIA LY-307,452 LY-341,495 MCPG MGS-0039 PCCG-4; Negative allosteric modulators: Decoglurant RO4491533

mGlu₃	Agonists: CBiPES DCG-IV Eglumegad Glutamate Ibotenic acid LY-379,268 LY-404,039 (pomaglumetad) LY-487,379 MGS-0028 Pomaglumetad methionil (LY-2140023) Talaglumetad Antagonists: APICA CECXG EGLU HYDIA LY-307,452 LY-341,495 MCPG MGS-0039; Negative allosteric modulators: Decoglurant RO4491533

mGlu₄	Agonists: Glutamate L-AP4 PHCCC VU-001,171 VU-0155,041; Positive allosteric modulators: MPEP Antagonists: CPPG MAP4 MPPG MSOP MTPG UBP-1112

mGlu₅	Agonists: ACPD ADX-47273 CDPPB CHPG DFB DHPG Glutamate Ibotenic acid Quisqualic acid VU-1545 Antagonists: CTEP DMeOB LY-344,545 Mavoglurant MCPG NPS-2390 Remeglurant SIB-1757 SIB-1893; Negative allosteric modulators: Basimglurant Dipraglurant Fenobam GRN-529 MPEP MTEP Raseglurant

mGlu₆	Agonists: Glutamate L-AP4 Antagonists: CPPG MAP4 MPPG MSOP MTPG UBP-1112

mGlu₇	Agonists: AMN082 Glutamate L-AP4 Antagonists: CPPG MAP4 MMPIP MPPG MSOP MTPG UBP-1112

mGlu₈	Agonists: DCPG Glutamate L-AP4 Antagonists: CPPG MAP4 MPPG MSOP MTPG UBP-1112

Transporter
(blockers)

EAATs	Amphetamine Aspartic acid (aspartate) cis-ACBD DHKA Glutamic acid (glutamate) HIP-A HIP-B Kainic acid L-(-)-threo-3-Hydroxyaspartic acid L-αAA L-CCG-III ((2S,3S,4R)-CCG) L-Serine-O-sulphate (SOS) L-trans-2,4-PDC MPDC SYM-2081 TBOA TFB-TBOA Theanine threo-3-Methylglutamic acid UCPH-101 WAY-213,613

vGluTs	4-Methylene-L-glutamate 6-(4'-Phenylstyryl)-QDC 6-Biphenyl-4-yl-QDC 7-CKA Acid red 114 Amido black 10B (naphthol blue black) Bafilomycin A1 Benzopurpurin 4B Bumetamide Chicago sky blue 6B Aspartic acid (aspartate) DIDS Direct blue 71 Erythro-4-methyl-L-glutamic acid Evans blue Furosemide Glutamic acid (glutamate) Kynurenic acid Nigericin NPPB (N144) Ponceau SS Reactive blue 2 Rose bengal SITS trans-ACDP Trypan blue Valinomycin Xanthurenic acid

Enzyme
(inhibitors)

GAH	BPTES CB-839 DON

AST	2-Amino-3-butenoic acid AAOA AMB β-DL-Methylene-aspartate Hydrazinosuccinate

ALT	β-Chloro-L-alanine L-Cycloserine Propargylglycine

GDH	AAOA Bithionol Chloroquine EGCG GTP GW5074 Hexachlorophene Hydroxylamine Palmitoyl-CoA Pyridoxal phosphate

GS	2-Aminoadipic acid JFD01307SC Methionine sulfoximine Phosphinothricin (glufosinate)

GAD	3-Mercaptopropionic acid AAOA L-Allylglycine Semicarbazide

Others

Precursors: GHB
L-Glutamine

Prodrugs: Aceglutamide (to L-glutamine)

See also: GABAergics • GHBergics • Glycinergics

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