LY-307,452

LY-307,452

Identifiers
IUPAC name (2S,4S)-2-amino-4-(4,4-diphenylbut-1-yl)pentan-1,5-dioic acid
PubChem (CID)	6324634
IUPHAR/BPS	3350
ChemSpider	4884363
Chemical and physical data
Formula	C21H25NO4
Molar mass	355.428 g/mol
3D model (Jmol)	Interactive image
SMILES C1=CC=C(C=C1)C(CCC[C@@H](C[C@@H](C(=O)O)N)C(=O)O)C2=CC=CC=C2
InChI InChI=1S/C21H25NO4/c22-19(21(25)26)14-17(20(23)24)12-7-13-18(15-8-3-1-4-9-15)16-10-5-2-6-11-16/h1-6,8-11,17-19H,7,12-14,22H2,(H,23,24)(H,25,26)/t17-,19-/m0/s1 Key:DWLOVDOPFJPWNE-HKUYNNGSSA-N
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LY-307,452 is a drug used in neuroscience research, which was among the first compounds found that acts as a selective antagonist for the group II metabotropic glutamate receptors (mGluR_2/3),^[1] and was useful in early studies of this receptor family,^[2][3] although it has largely been replaced by newer drugs such as LY-341,495.

References

1. Wermuth CG, Mann A, Schoenfelder A, Wright RA, Johnson BG, Burnett JP, Mayne NG, Schoepp DD (February 1996). "(2S,4S)-2-amino-4-(4,4-diphenylbut-1-yl)-pentane-1,5-dioic acid: a potent and selective antagonist for metabotropic glutamate receptors negatively linked to adenylate cyclase". Journal of Medicinal Chemistry. 39 (4): 814–6. doi:10.1021/jm9508144. PMID 8632404.
2. Li XC, Beart PM, Monn JA, Jones NM, Widdop RE (October 1999). "Type I and II metabotropic glutamate receptor agonists and antagonists evoke cardiovascular effects after intrathecal administration in conscious rats". British Journal of Pharmacology. 128 (3): 823–9. doi:10.1038/sj.bjp.0702850. PMC 1571690. PMID 10516668.
3. Sung KW, Choi S, Lovinger DM (November 2001). "Activation of group I mGluRs is necessary for induction of long-term depression at striatal synapses". Journal of Neurophysiology. 86 (5): 2405–12. PMID 11698530.