Manidipine

Manidipine

Clinical data
Trade names	Manyper, etc.
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
ATC code	C08CA11 (WHO)
Legal status
Legal status	℞ (Prescription only)
Identifiers
IUPAC name 2-[4-(Diphenylmethyl)piperazin-1-yl]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS Number	89226-50-6 120092-68-4
PubChem (CID)	4008
ChemSpider	3868
UNII	6O4754US88
Chemical and physical data
Formula	C35H38N4O6
Molar mass	610.69 g/mol
3D model (Jmol)	Interactive image
SMILES [O-][N+](=O)c1cccc(c1)C5C(/C(=O)OC)=C(\N\C(=C5\C(=O)OCCN4CCN(C(c2ccccc2)c3ccccc3)CC4)C)C
InChI InChI=1S/C35H38N4O6/c1-24-30(34(40)44-3)32(28-15-10-16-29(23-28)39(42)43)31(25(2)36-24)35(41)45-22-21-37-17-19-38(20-18-37)33(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-16,23,32-33,36H,17-22H2,1-3H3

Manidipine (INN) is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive.^{[1][2][3][4][5]}

References

1. Cheer, S.M.; McClellan, K. (2001), "Manidipine: A Review of its Use in Hypertension", Drugs, 61 (12): 1777–99, doi:10.2165/00003495-200161120-00010, PMID 11693466, retrieved 2009-06-20
2. McKeage, K.; Scott, L.J. (2004), "Manidipine: A Review of its Use in the Management of Hypertension", Drugs, 64 (17): 1923–40, doi:10.2165/00003495-200464170-00011, PMID 15329044, retrieved 2009-06-20
3. Roca-cusachs, A.; Triposkiadis, F. (2005), "Antihypertensive Effect of Manidipine", Drugs, 65: 11–9, doi:10.2165/00003495-200565002-00003, PMID 16398058, retrieved 2009-06-20
4. Otero, M.L. (2007), "Manidipine–delapril combination in the management of hypertension", Vascular Health and Risk Management, 3 (3): 255–63, PMC 2293964, PMID 17703633
5. Mizuno, Kenji; Haga, Hiroshi; Takahashi, Michihiko; Fukuchi, Soitsu (August 1992), "Evaluation of manidipine hydrochloride, a new calcium antagonist, in the treatment of hypertensive patients with renal disorders", Current Therapeutic Research, 52 (2): 248–253, doi:10.1016/S0011-393X(05)80475-8, retrieved 2009-06-20