Clopenthixol

Clopenthixol

Clinical data
Routes of administration	Oral
ATC code	N05AF02 (WHO)
Identifiers
IUPAC name (E,Z)-2-[4-[3-(2-chlorothioxanthen-9-ylidene) propyl]piperazin-1-yl]ethanol
CAS Number	982-24-1
PubChem (CID)	12454
ChemSpider	11945
UNII	FLE878A8ZI
KEGG	D02613
ChEMBL	CHEMBL53904
ECHA InfoCard	100.012.333
Chemical and physical data
Formula	C22H25ClN2OS
Molar mass	400.965 g/mol
3D model (Jmol)	Interactive image
SMILES Clc2cc1C(c3c(Sc1cc2)cccc3)=CCCN4CCN(CCO)CC4
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Clopenthixol (Sordinol), also known as clopentixol, is a typical antipsychotic drug of the thioxanthene class. It was introduced by Lundbeck in 1961.^[1]

Clopenthixol is a mixture of cis and trans isomers. Zuclopenthixol, the pure cis isomer, was later introduced by Lundbeck in 1962,^[2] and has been much more widely used. Both drugs are equally effective as antipsychotics and have similar adverse effect profiles, but clopenthixol is half as active on a milligram-to-milligram basis and appears to produce more sedation in comparison.^[3]

Clopenthixol is not approved for use in the United States.

See also

• Typical antipsychotic
• Thioxanthene

References

1. Sneader, Walter (2005). Drug discovery: a history. New York: Wiley. p. 410. ISBN 0-471-89980-1.
2. José Miguel Vela; Helmut Buschmann; Jörg Holenz; Antonio Párraga; Antoni Torrens (2007). Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. Weinheim: Wiley-VCH. p. 516. ISBN 3-527-31058-4.
3. Gravem A, Engstrand E, Guleng RJ (November 1978). "Cis(Z)-clopenthixol and clopenthixol (Sordinol) in chronic psychotic patients. A double-blind clinical investigation". Acta Psychiatr Scand. 58 (5): 384–8. doi:10.1111/j.1600-0447.1978.tb03570.x. PMID 362830.

External links

• Clopenthixol at the US National Library of Medicine Medical Subject Headings (MeSH)