SB-204070

SB-204070

Identifiers
IUPAC name (1-butyl-4-piperidinyl)methyl-8-amino-7-chloro-1,4-benzodioxane-5-carboxylate
CAS Number	148688-01-1
PubChem (CID)	121881
IUPHAR/BPS	256
ChEMBL	CHEMBL68131
Chemical and physical data
Formula	C19H27ClN2O4
Molar mass	382.881 g/mol
3D model (Jmol)	Interactive image
SMILES Nc1c2OCCOc2c(cc1Cl)C(=O)OCC3CCN(CCCC)CC3

SB-204070 is a drug which acts as a potent and selective 5-HT₄ serotonin receptor antagonist (or weak partial agonist), and is used for research into the function of this receptor subtype.^{[1][2][3][4][5]}

References

1. Mialet J; Berque-Bestel I; Sicsic S; Langlois M; Fischmeister R; Lezoualc'h F (October 2000). "Pharmacological characterization of the human 5-HT(4(d)) receptor splice variant stably expressed in Chinese hamster ovary cells". British Journal of Pharmacology. 131 (4): 827–35. doi:10.1038/sj.bjp.0703641. PMC 1572397. PMID 11030734.
2. Pindon A; van Hecke G; van Gompel P; Lesage AS; Leysen JE; Jurzak M (January 2002). "Differences in signal transduction of two 5-HT4 receptor splice variants: compound specificity and dual coupling with Galphas- and Galphai/o-proteins". Molecular Pharmacology. 61 (1): 85–96. doi:10.1124/mol.61.1.85. PMID 11752209.
3. Takahashi H; Takada Y; Urano T; Takada A (2002). "5-HT4 receptors in the hippocampus modulate rat locomotor activity". Hippocampus. 12 (3): 304–10. doi:10.1002/hipo.10012. PMID 12099482.
4. Sakurai-Yamashita Y; Yamashita K; Niwa M; Taniyama K (May 2003). "Involvement of 5-hydroxytryptamine4 receptor in the exacerbation of neuronal loss by psychological stress in the hippocampus of SHRSP with a transient ischemia". Brain Research. 973 (1): 92–8. doi:10.1016/S0006-8993(03)02559-9. PMID 12729957.
5. Smith AJ; Chappell AE; Buret AG; Barrett KE; Dong H (December 2006). "5-Hydroxytryptamine contributes significantly to a reflex pathway by which the duodenal mucosa protects itself from gastric acid injury". The FASEB Journal. 20 (14): 2486–95. doi:10.1096/fj.06-6391com. PMID 17142798.