Alstonine

Alstonine
Clinical data
ATC code none
Identifiers
CAS Number 642-18-2
PubChem (CID) 441979
ChemSpider 149308
Chemical and physical data
Formula C21H21N2O3
Molar mass 349.402496 g/mol
3D model (Jmol) Interactive image

Alstonine is an indole alkaloid and putative antipsychotic constituent of various plant species including Alstonia boonei, Catharanthus roseus, Picralima nitida, Rauwolfia caffra and Rauwolfia vomitoria.[1] In preclinical studies alstonine attenuates MK-801-induced hyperlocomotion, working memory deficit and social withdrawal.[2] It also possesses anxiolytic-like effects in preclinical studies,[1] attenuates amphetamine-induced lethality and stereotypy as well as apomorphine-induced stereotypy,[1] and attenuates haloperidol-induced catalepsy.[3] These effects appear to be mediated by stimulation of the 5-HT2C receptor.[4] In addition, alstonine, similarly to clozapine, indirectly inhibits the reuptake of glutamate in hippocampal slices.[5] Unlike clozapine however, the effect of which is abolished by the D2 receptor agonist apomorphine, alstonine requires 5-HT2A and 5-HT2C receptors to produce this effect, as it is abolished by antagonists of these receptors. Also unlike clozapine, alstonine lacks pro-convulsant activity in mice.[6]

References

  1. 1 2 3 Elisabetsky, E; Costa-Campos, L (March 2006). "The Alkaloid Alstonine: A Review of Its Pharmacological Properties" (PDF). Evidence-based Complementary and Alternative Medicine. 3 (1): 39–48. doi:10.1093/ecam/nek011. PMC 1375234Freely accessible. PMID 16550222.
  2. ↑ Linck, VM; Bessa, MM; Herrmann, AP; Iwu, MM; Okunji, CO; Elisabetsky, E (January 2012). "5-HT2A/C receptors mediate the antipsychotic-like effects of alstonine". Progress in Neuro-Psychopharmacology and Biological Psychiatry. 36 (1): 29–33. doi:10.1016/j.pnpbp.2011.08.022. PMID 21925231.
  3. ↑ Linck, VM; Herrmann, AP; Piato, LN; Detanico, BC; Figueir, M; Flório, J; Iwu, MM; Okunji, CO; Leal, MB; Elisabetsky, E (July 2011). "Alstonine as an Antipsychotic: Effects on Brain Amines and Metabolic Changes" (PDF). Evidence-Based Complementary and Alternative Medicine. 2011 (418597). doi:10.1093/ecam/nep002.
  4. ↑ Gross, G; Geyer, MA, eds. (2012). Current Antipsychotics. Handbook of Experimental Pharmacology. 212. Springer Berlin Heidelberg. p. 107. doi:10.1007/978-3-642-25761-2. ISBN 978-3-642-25761-2. ISSN 1865-0325.
  5. ↑ Herrmann, AP; Lunardi, P; Pilz, LK; Tramontina, AC; Linck, VM; Okunji, CO; Gonçalves, CA; Elisabetsky, E (December 2012). "Effects of the putative antipsychotic alstonine on glutamate uptake in acute hippocampal slices". Neurochemistry International. 61 (7): 1144–1150. doi:10.1016/j.neuint.2012.08.006. PMID 22940693.
  6. ↑ Costa-Campos L, Iwu M, Elisabetsky E (August 2004). "Lack of pro-convulsant activity of the antipsychotic alkaloid alstonine". Journal of Ethnopharmacology. 93 (2-3): 307–310. doi:10.1016/j.jep.2004.03.056. PMID 15234769.


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