FZD2

FZD2
Identifiers
Aliases	FZD2, Fz2, fz-2, fzE2, hFz2, frizzled class receptor 2
External IDs	MGI: 1888513 HomoloGene: 20377 GeneCards: FZD2
Gene ontology Molecular function • PDZ domain binding • G-protein coupled receptor activity • signal transducer activity • Wnt-protein binding • protein binding • Wnt-activated receptor activity • transmembrane signaling receptor activity Cellular component • cytoplasm • integral component of membrane • clathrin-coated endocytic vesicle membrane • membrane • focal adhesion • plasma membrane Biological process • G-protein coupled receptor signaling pathway • non-canonical Wnt signaling pathway • epithelial cell differentiation • muscular septum morphogenesis • ventricular septum morphogenesis • cell-cell signaling • membranous septum morphogenesis • outflow tract morphogenesis • positive regulation of sequence-specific DNA binding transcription factor activity • Wnt signaling pathway • planar cell polarity pathway involved in neural tube closure • positive regulation of transcription, DNA-templated • multicellular organism development • sensory perception of smell • cell surface receptor signaling pathway • inner ear receptor cell development • hard palate development • cochlea morphogenesis • neuron differentiation • canonical Wnt signaling pathway • positive regulation of cGMP metabolic process • signal transduction • beta-catenin destruction complex disassembly • Wnt signaling pathway, calcium modulating pathway • Wnt signaling pathway, planar cell polarity pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2535	57265
Ensembl	ENSG00000180340	ENSMUSG00000050288
UniProt	Q14332	Q9JIP6
RefSeq (mRNA)	NM_001466	NM_020510
RefSeq (protein)	NP_001457.1	NP_065256.1
Location (UCSC)	Chr 17: 44.56 – 44.56 Mb	Chr 11: 102.6 – 102.61 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

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Frizzled-2 is a protein that in humans is encoded by the FZD2 gene.^[3][4][5]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The expression of the FZD2 gene appears to be developmentally regulated, with high levels of expression in fetal kidney and lung and in adult colon and ovary.^[5]

See also

• Frizzled

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Zhao Z, Lee CC, Baldini A, Caskey CT (Nov 1995). "A human homologue of the Drosophila polarity gene frizzled has been identified and mapped to 17q21.1". Genomics. 27 (2): 370–3. doi:10.1006/geno.1995.1060. PMID 7558010.
4. Sagara N, Toda G, Hirai M, Terada M, Katoh M (Dec 1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7". Biochem Biophys Res Commun. 252 (1): 117–22. doi:10.1006/bbrc.1998.9607. PMID 9813155.
5. "Entrez Gene: FZD2 frizzled homolog 2 (Drosophila)".

External links

• "Frizzled Receptors: FZD₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

Further reading

• Wang Y, Macke JP, Abella BS, et al. (1996). "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled.". J. Biol. Chem. 271 (8): 4468–76. doi:10.1074/jbc.271.8.4468. PMID 8626800.
• Finch PW, He X, Kelley MJ, et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. doi:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640.
• Tanaka S, Akiyoshi T, Mori M, et al. (1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164–9. doi:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618.
• Hering H, Sheng M (2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95.". FEBS Lett. 521 (1–3): 185–9. doi:10.1016/S0014-5793(02)02831-4. PMID 12067714.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Oishi I, Suzuki H, Onishi N, et al. (2004). "The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway". Genes Cells. 8 (7): 645–54. doi:10.1046/j.1365-2443.2003.00662.x. PMID 12839624.
• Omoto S, Hayashi T, Kitahara K, et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.