Prolactin-releasing peptide receptor

PRLHR
Identifiers
Aliases	PRLHR, GPR10, GR3, PrRPR, prolactin releasing hormone receptor
External IDs	MGI: 2135956 HomoloGene: 3134 GeneCards: PRLHR
Gene ontology Molecular function • neuropeptide Y receptor activity • G-protein coupled receptor activity • protein binding • signal transducer activity • neuropeptide receptor activity Cellular component • integral component of membrane • plasma membrane • integral component of plasma membrane • membrane Biological process • female pregnancy • G-protein coupled receptor signaling pathway • cell surface receptor signaling pathway • hormone metabolic process • feeding behavior • signal transduction • neuropeptide signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2834	226278
Ensembl	ENSG00000119973	ENSMUSG00000045052
UniProt	P49683	Q6VMN6
RefSeq (mRNA)	NM_004248	NM_201615
RefSeq (protein)	NP_004239.1	NP_963909.2
Location (UCSC)	Chr 10: 118.59 – 118.6 Mb	Chr 19: 60.47 – 60.47 Mb
PubMed search	[1]	[2]
Wikidata

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The prolactin-releasing peptide receptor (PrRPR) also known as G-protein coupled receptor 10 (GPR10) is a protein that in humans is encoded by the PRLHR gene.

PrRPR is a G-protein coupled receptor^[3] that binds the prolactin-releasing peptide (PRLH).^[4]

Function

PrRPR is a 7-transmembrane domain receptor for prolactin-releasing peptide that is highly expressed in the anterior pituitary.^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Marchese A, Heiber M, Nguyen T, Heng HH, Saldivia VR, Cheng R, Murphy PM, Tsui LC, Shi X, Gregor P (1995). "Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors". Genomics. 29 (2): 335–44. doi:10.1006/geno.1995.9996. PMID 8666380.
4. Hinuma S, Habata Y, Fujii R, Kawamata Y, Hosoya M, Fukusumi S, Kitada C, Masuo Y, Asano T, Matsumoto H, Sekiguchi M, Kurokawa T, Nishimura O, Onda H, Fujino M (1998). "A prolactin-releasing peptide in the brain". Nature. 393 (6682): 272–6. doi:10.1038/30515. PMID 9607765.
5. "Entrez Gene: PRLHR prolactin releasing hormone receptor".

Further reading

• Hinuma S, Onda H, Fujino M (1999). "The quest for novel bioactive peptides utilizing orphan seven-transmembrane-domain receptors.". J. Mol. Med. 77 (6): 495–504. doi:10.1007/s001090050403. PMID 10475064.
• Marchese A, Heiber M, Nguyen T, et al. (1996). "Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors.". Genomics. 29 (2): 335–44. doi:10.1006/geno.1995.9996. PMID 8666380.
• Hinuma S, Habata Y, Fujii R, et al. (1998). "A prolactin-releasing peptide in the brain.". Nature. 393 (6682): 272–6. doi:10.1038/30515. PMID 9607765.
• Fujii R, Fukusumi S, Hosoya M, et al. (1999). "Tissue distribution of prolactin-releasing peptide (PrRP) and its receptor.". Regul. Pept. 83 (1): 1–10. doi:10.1016/S0167-0115(99)00028-2. PMID 10498338.
• Langmead CJ, Szekeres PG, Chambers JK, et al. (2000). "Characterization of the binding of [(125)I]-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor.". Br. J. Pharmacol. 131 (4): 683–8. doi:10.1038/sj.bjp.0703617. PMC 1572376. PMID 11030716.
• Lin SH, Arai AC, Wang Z, et al. (2001). "The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering.". Mol. Pharmacol. 60 (5): 916–23. PMID 11641419.
• Ozawa A, Yamada M, Satoh T, et al. (2002). "Transcriptional regulation of the human PRL-releasing peptide (PrRP) receptor gene by a dopamine 2 Receptor agonist: cloning and characterization of the human PrRP receptor gene and its promoter region.". Mol. Endocrinol. 16 (4): 785–98. doi:10.1210/me.16.4.785. PMID 11923475.
• Takahashi K, Totsune K, Murakami O, et al. (2003). "Expression of prolactin-releasing peptide and its receptor in the human adrenal glands and tumor tissues of adrenocortical tumors, pheochromocytomas and neuroblastomas.". Peptides. 23 (6): 1135–40. doi:10.1016/S0196-9781(02)00046-3. PMID 12126742.
• Kemp DM, Lin JC, Ubeda M, Habener JF (2002). "NRSF/REST confers transcriptional repression of the GPR10 gene via a putative NRSE/RE-1 located in the 5' promoter region.". FEBS Lett. 531 (2): 193–8. doi:10.1016/S0014-5793(02)03502-0. PMID 12417311.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bhattacharyya S, Luan J, Challis B, et al. (2003). "Association of polymorphisms in GPR10, the gene encoding the prolactin-releasing peptide receptor with blood pressure, but not obesity, in a U.K. Caucasian population.". Diabetes. 52 (5): 1296–9. doi:10.2337/diabetes.52.5.1296. PMID 12716769.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ellacott KL, Donald EL, Clarkson P, et al. (2005). "Characterization of a naturally-occurring polymorphism in the UHR-1 gene encoding the putative rat prolactin-releasing peptide receptor.". Peptides. 26 (4): 675–81. doi:10.1016/j.peptides.2004.11.020. PMID 15752583.
• Lagerström MC, Fredriksson R, Bjarnadóttir TK, et al. (2005). "Origin of the prolactin-releasing hormone (PRLH) receptors: evidence of coevolution between PRLH and a redundant neuropeptide Y receptor during vertebrate evolution.". Genomics. 85 (6): 688–703. doi:10.1016/j.ygeno.2005.02.007. PMID 15885496.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

External links

• "Prolactin-Releasing Peptide Receptor". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
• PRLHR protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.