LPAR1

LPAR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4Z34, 4Z35, 4Z36
Identifiers
Aliases	LPAR1, EDG2, GPR26, Gpcr26, LPA1, Mrec1.3, VZG1, edg-2, rec.1.3, vzg-1, lysophosphatidic acid receptor 1
External IDs	MGI: 108429 HomoloGene: 1072 GeneCards: LPAR1
Gene ontology Molecular function • lysophosphatidic acid binding • PDZ domain binding • G-protein coupled receptor activity • signal transducer activity • protein binding • lysophosphatidic acid receptor activity • G-protein alpha-subunit binding • phospholipid binding • lipid binding Cellular component • cytoplasm • integral component of membrane • endosome • membrane • plasma membrane • dendritic spine • endocytic vesicle • integral component of plasma membrane • dendritic shaft • cell surface • neuronal cell body • neuron projection Biological process • positive regulation of Rho protein signal transduction • positive regulation of smooth muscle cell chemotaxis • G-protein coupled receptor signaling pathway • neurogenesis • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway • negative regulation of neuron projection development • positive regulation of cell death • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • positive regulation of cytosolic calcium ion concentration • bleb assembly • positive regulation of dendritic spine development • activation of phospholipase C activity • cerebellum development • cellular response to 1-oleoyl-sn-glycerol 3-phosphate • brain development • activation of MAPK activity • negative regulation of cAMP biosynthetic process • regulation of cell shape • positive regulation of apoptotic process • cell chemotaxis • positive regulation of I-kappaB kinase/NF-kappaB signaling • myelination • oligodendrocyte development • corpus callosum development • cellular response to oxygen levels • positive regulation of stress fiber assembly • optic nerve development • positive regulation of MAPK cascade • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1902	14745
Ensembl	ENSG00000198121	ENSMUSG00000038668
UniProt	Q92633	P61793
RefSeq (mRNA)	NM_001401 NM_057159	NM_001290486 NM_010336 NM_172989
RefSeq (protein)	NP_001392.2 NP_476500.1	NP_001277415.1 NP_034466.2 NP_766577.1
Location (UCSC)	Chr 9: 110.87 – 111.04 Mb	Chr 4: 58.44 – 58.55 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

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Lysophosphatidic acid receptor 1 also known as LPA₁ is a protein that in humans is encoded by the LPAR1 gene.^[3][4][5] LPA₁ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).^[6]

Function

The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Alternative splicing of this gene has been observed and two transcript variants have been described, each encoding identical proteins. An alternate translation start codon has been identified, which results in isoforms differing in the N-terminal extracellular tail. In addition, an alternate polyadenylation site has been reported.^[3]

See also

• Lysophospholipid receptor

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: LPAR1 Lysophosphatidic acid receptor 1".
4. Hecht JH, Weiner JA, Post SR, Chun J (November 1996). "Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex". J. Cell Biol. 135 (4): 1071–83. doi:10.1083/jcb.135.4.1071. PMC 2133395. PMID 8922387.
5. An S, Dickens MA, Bleu T, Hallmark OG, Goetzl EJ (February 1997). "Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid". Biochem. Biophys. Res. Commun. 231 (3): 619–22. doi:10.1006/bbrc.1997.6150. PMID 9070858.
6. Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.

Further reading

• An S, Goetzl EJ, Lee H (1999). "Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate.". J. Cell. Biochem. Suppl. 30-31: 147–57. PMID 9893266.
• Contos JJ, Ishii I, Chun J (2001). "Lysophosphatidic acid receptors.". Mol. Pharmacol. 58 (6): 1188–96. PMID 11093753.
• Moolenaar WH, Kranenburg O, Postma FR, Zondag GC (1997). "Lysophosphatidic acid: G-protein signalling and cellular responses.". Curr. Opin. Cell Biol. 9 (2): 168–73. doi:10.1016/S0955-0674(97)80059-2. PMID 9069262.
• Fukushima N, Kimura Y, Chun J (1998). "A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid.". Proc. Natl. Acad. Sci. U.S.A. 95 (11): 6151–6. doi:10.1073/pnas.95.11.6151. PMC 27607. PMID 9600933.
• An S, Bleu T, Zheng Y, Goetzl EJ (1998). "Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization.". Mol. Pharmacol. 54 (5): 881–8. PMID 9804623.
• Cervera P, Tirard M, Barron S, et al. (2002). "Immunohistological localization of the myelinating cell-specific receptor LP(A1).". Glia. 38 (2): 126–36. doi:10.1002/glia.10054. PMID 11948806.
• Hama K, Bandoh K, Kakehi Y, et al. (2002). "Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors.". FEBS Lett. 523 (1-3): 187–92. doi:10.1016/S0014-5793(02)02976-9. PMID 12123830.
• Van Leeuwen FN, Olivo C, Grivell S, et al. (2003). "Rac activation by lysophosphatidic acid LPA1 receptors through the guanine nucleotide exchange factor Tiam1.". J. Biol. Chem. 278 (1): 400–6. doi:10.1074/jbc.M210151200. PMID 12393875.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Murph MM, Scaccia LA, Volpicelli LA, Radhakrishna H (2004). "Agonist-induced endocytosis of lysophosphatidic acid-coupled LPA1/EDG-2 receptors via a dynamin2- and Rab5-dependent pathway.". J. Cell. Sci. 116 (Pt 10): 1969–80. doi:10.1242/jcs.00397. PMID 12668728.
• Shida D, Kitayama J, Yamaguchi H, et al. (2003). "Lysophosphatidic acid (LPA) enhances the metastatic potential of human colon carcinoma DLD1 cells through LPA1.". Cancer Res. 63 (7): 1706–11. PMID 12670925.
• Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
• Xu J, Lai YJ, Lin WC, Lin FT (2004). "TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor.". J. Biol. Chem. 279 (11): 10459–68. doi:10.1074/jbc.M311891200. PMID 14688263.
• Komuro Y, Watanabe T, Kitayama J, et al. (2004). "The Immunohistochemical expression of endothelial cell differentiation gene-2 receptor in human colorectal adenomas.". Hepatogastroenterology. 50 (54): 1770–3. PMID 14696401.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Kaneider NC, Lindner J, Feistritzer C, et al. (2005). "The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor.". FASEB J. 18 (11): 1309–11. doi:10.1096/fj.03-1050fje. PMID 15208267.

External links

• "Lysophospholipid Receptors: LPA₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
• Lysophospholipid receptors at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.