Somatostatin receptor 4

SSTR4
Identifiers
Aliases	SSTR4, SS-4-R, SS4-R, SS4R, Somatostatin receptor 4
External IDs	MGI: 105372 HomoloGene: 20286 GeneCards: SSTR4
Gene ontology Molecular function • somatostatin receptor activity • neuropeptide binding • G-protein coupled receptor activity • signal transducer activity Cellular component • cytoplasm • integral component of membrane • neuron projection • plasma membrane • integral component of plasma membrane • membrane Biological process • G-protein coupled receptor signaling pathway • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • forebrain development • cellular response to glucocorticoid stimulus • negative regulation of cAMP metabolic process • cell migration • arachidonic acid metabolic process • positive regulation of MAPK cascade • negative regulation of cell proliferation • signal transduction • somatostatin signaling pathway • chemical synaptic transmission Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6754	20608
Ensembl	ENSG00000132671	ENSMUSG00000037014
UniProt	P31391	P49660
RefSeq (mRNA)	NM_001052	NM_009219
RefSeq (protein)	NP_001043.2	NP_033245.2
Location (UCSC)	Chr 20: 23.04 – 23.04 Mb	Chr 2: 148.4 – 148.4 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Somatostatin receptor type 4 is a protein that in humans is encoded by the SSTR4 gene.^[3][4]

Function

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung.^[4]

See also

• Somatostatin receptor

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Rohrer L, Raulf F, Bruns C, Buettner R, Hofstaedter F, Schüle R (May 1993). "Cloning and characterization of a fourth human somatostatin receptor". Proceedings of the National Academy of Sciences of the United States of America. 90 (9): 4196–200. doi:10.1073/pnas.90.9.4196. PMC 46473. PMID 8483934.
4. "Entrez Gene: SSTR4 somatostatin receptor 4".

Further reading

• Patel YC (July 1999). "Somatostatin and its receptor family". Frontiers in Neuroendocrinology. 20 (3): 157–98. doi:10.1006/frne.1999.0183. PMID 10433861.
• Yamada Y, Post SR, Wang K, Tager HS, Bell GI, Seino S (January 1992). "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney". Proceedings of the National Academy of Sciences of the United States of America. 89 (1): 251–5. doi:10.1073/pnas.89.1.251. PMC 48214. PMID 1346068.
• Demchyshyn LL, Srikant CB, Sunahara RK, Kent G, Seeman P, Van Tol HH, Panetta R, Patel YC, Niznik HB (June 1993). "Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20". Molecular Pharmacology. 43 (6): 894–901. PMID 8100352.
• Yasuda K, Espinosa R, Davis EM, Le Beau MM, Bell GI (September 1993). "Human somatostatin receptor genes: localization of SSTR5 to human chromosome 20p11.2". Genomics. 17 (3): 785–6. doi:10.1006/geno.1993.1410. PMID 8244401.
• Yamada Y, Kagimoto S, Kubota A, Yasuda K, Masuda K, Someya Y, Ihara Y, Li Q, Imura H, Seino S (September 1993). "Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype". Biochemical and Biophysical Research Communications. 195 (2): 844–52. doi:10.1006/bbrc.1993.2122. PMID 8373420.
• Kaupmann K, Bruns C, Hoyer D, Seuwen K, Lübbert H (September 1993). "Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain". FEBS Letters. 331 (1-2): 53–9. doi:10.1016/0014-5793(93)80296-7. PMID 8405411.
• Yamada Y, Stoffel M, Espinosa R, Xiang KS, Seino M, Seino S, Le Beau MM, Bell GI (February 1993). "Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms". Genomics. 15 (2): 449–52. doi:10.1006/geno.1993.1088. PMID 8449518.
• Xu Y, Song J, Bruno JF, Berelowitz M (June 1993). "Molecular cloning and sequencing of a human somatostatin receptor, hSSTR4". Biochemical and Biophysical Research Communications. 193 (2): 648–52. doi:10.1006/bbrc.1993.1673. PMID 8512564.
• Fukusumi S, Kitada C, Takekawa S, Kizawa H, Sakamoto J, Miyamoto M, Hinuma S, Kitano K, Fujino M (March 1997). "Identification and characterization of a novel human cortistatin-like peptide". Biochemical and Biophysical Research Communications. 232 (1): 157–63. doi:10.1006/bbrc.1997.6252. PMID 9125122.
• de Lecea L, Ruiz-Lozano P, Danielson PE, Peelle-Kirley J, Foye PE, Frankel WN, Sutcliffe JG (June 1997). "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin". Genomics. 42 (3): 499–506. doi:10.1006/geno.1997.4763. PMID 9205124.
• Jaïs P, Terris B, Ruszniewski P, LeRomancer M, Reyl-Desmars F, Vissuzaine C, Cadiot G, Mignon M, Lewin MJ (August 1997). "Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours". European Journal of Clinical Investigation. 27 (8): 639–44. doi:10.1046/j.1365-2362.1997.1740719.x. PMID 9279525.
• Sharma K, Patel YC, Srikant CB (January 1999). "C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest". Molecular Endocrinology. 13 (1): 82–90. doi:10.1210/me.13.1.82. PMID 9892014.
• Forssell-Aronsson EB, Nilsson O, Bejegård SA, Kölby L, Bernhardt P, Mölne J, Hashemi SH, Wängberg B, Tisell LE, Ahlman H (April 2000). "111In-DTPA-D-Phe1-octreotide binding and somatostatin receptor subtypes in thyroid tumors". Journal of Nuclear Medicine. 41 (4): 636–42. PMID 10768564.
• Zatelli MC, Tagliati F, Taylor JE, Rossi R, Culler MD, degli Uberti EC (May 2001). "Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt". The Journal of Clinical Endocrinology and Metabolism. 86 (5): 2161–9. doi:10.1210/jc.86.5.2161. PMID 11344221.
• Talme T, Ivanoff J, Hägglund M, Van Neerven RJ, Ivanoff A, Sundqvist KG (July 2001). "Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3". Clinical and Experimental Immunology. 125 (1): 71–9. doi:10.1046/j.1365-2249.2001.01577.x. PMC 1906108. PMID 11472428.
• Pasquali D, Notaro A, Esposito D, Vassallo P, Bonavolontà G, Bellastella A, Sinisi AA (September 2001). "[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy]". Minerva Endocrinologica. 26 (3): 175–9. PMID 11753241.
• Papotti M, Bongiovanni M, Volante M, Allìa E, Landolfi S, Helboe L, Schindler M, Cole SL, Bussolati G (May 2002). "Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis". Virchows Archiv. 440 (5): 461–75. doi:10.1007/s00428-002-0609-x. PMID 12021920.

External links

• "Somatostatin Receptors: sst₄". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
• somatostatin receptor subtype-4 at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.