HU-243

HU-243

Identifiers
IUPAC name (6aR,8S,9S,10aR)-9-(hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-8,9-ditritio-7,8,10,10a-tetrahydro-6aH-benzo[c]chromen-1-ol
CAS Number	140835-18-3
PubChem (CID)	3081854
IUPHAR/BPS	735
Chemical and physical data
Formula	C25H40O3
Molar mass	388.30 g/mol
3D model (Jmol)	Interactive image
SMILES CC(O1)(C)[C@H]2[C@@H](C[C@H](CO)CC2)C3=C1C=C(C(C)(C)CCCCCC)C=C3O

HU-243 (AM-4056) is a synthetic cannabinoid drug that is a single enantiomer of the hydrogenated derivative of the commonly used reference agonist HU-210. It is a potent agonist at both the CB₁ and CB₂ receptors, with a binding affinity of 0.041 nM at the CB₁ receptor, making it marginally more potent than HU-210, which had an affinity of 0.061 nM in the same assay.^[1]

See also

• AM-2389
• Nabidrox
• Nabilone

References

1. Stern, E.; Lambert, D. M. (2007). "Medicinal Chemistry Endeavors around the Phytocannabinoids". Chemistry & Biodiversity. 4 (8): 1707–1728. doi:10.1002/cbdv.200790149. PMID 17712816.