L-759,656

L-759,656

Identifiers
IUPAC name (6aR,10aR)-1-methoxy-6,6-dimethyl-9-methylidene-3-(2-methyloctan-2-yl)-7,8,10,10a-tetrahydro-6aH-benzo[c]chromene
PubChem (CID)	5311216
IUPHAR/BPS	749
ChemSpider	4470735
ChEMBL	CHEMBL294013
Chemical and physical data
Formula	C26H40O2
Molar mass	384.593 g/mol
3D model (Jmol)	Interactive image
SMILES CCCCCCC(C)(C)c1cc2c(c(c1)OC)[C@@H]3CC(=C)CC[C@H]3C(O2)(C)C
InChI InChI=1S/C26H40O2/c1-8-9-10-11-14-25(3,4)19-16-22(27-7)24-20-15-18(2)12-13-21(20)26(5,6)28-23(24)17-19/h16-17,20-21H,2,8-15H2,1,3-7H3/t20-,21-/m1/s1 Key:BJIIKHXAZBTGLF-NHCUHLMSSA-N
(what is this?)  (verify)

L-759,656 is an analgesic drug that is a cannabinoid agonist. It is a highly selective agonist for the CB₂ receptor, with selectivity of 414x for CB₂ over CB₁,^[1] although it is still not as selective as newer agents such as HU-308.

It produces some similar effects to other cannabinoid agonists such as analgesia, but with little or no sedative or psychoactive effects due to its weak CB₁ activity, and a relatively strong antiinflammatory effect due to its strong activity at CB₂.^[2][3]

See also

• L-759,633
• L-768,242

References

1. Ross, R.; Brockie, H.; Stevenson, L.; Murphy, V.; Templeton, F.; Makriyannis, A.; Pertwee, R. (1999). "Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630". British Journal of Pharmacology. 126 (3): 665–672. doi:10.1038/sj.bjp.0702351. PMC 1565857. PMID 10188977.
2. Huffman, J. W. (2000). "The search for selective ligands for the CB2 receptor". Current pharmaceutical design. 6 (13): 1323–1337. doi:10.2174/1381612003399347. PMID 10903395.
3. Huffman, J. W. (2005). "CB2 receptor ligands". Mini reviews in medicinal chemistry. 5 (7): 641–649. doi:10.2174/1389557054368844. PMID 16026310.