JWH-185

JWH-185

Legal status
Legal status	UK: Class B
Identifiers
IUPAC name 3-[(4-methoxy-1-naphthalenyl)methyl]-1-pentyl-1H-indole
CAS Number	619294-39-2
ChemSpider	35303440
Chemical and physical data
Formula	C25H27NO
Molar mass	357.49 g/mol
3D model (Jmol)	Interactive image
SMILES CCCCCn1cc(c2c1cccc2)Cc3ccc(c4c3cccc4)OC
InChI InChI=1S/C25H27NO/c1-3-4-9-16-26-18-20(22-11-7-8-13-24(22)26)17-19-14-15-25(27-2)23-12-6-5-10-21(19)23/h5-8,10-15,18H,3-4,9,16-17H2,1-2H3 Key:OTYBPWBZUDBUQS-UHFFFAOYSA-N

JWH-185 is a synthetic cannabinoid receptor ligand from the naphthoylindole family. It is the carbonyl-reduced derivative of related compound JWH-081. The binding affinity of JWH-185 for the CB₁ receptor is reported as K_i = 17 ± 3 nM.^[1]

See also

• JWH-081
• JWH-184

References

1. Huffman JW, Mabon R, Wu MJ, Lu J, Hart R, Hurst DP, Reggio PH, Wiley JL, Martin BR (2003). "3-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB1 cannabinoid receptor". Bioorg. Med. Chem. 11 (4): 539–549. doi:10.1016/s0968-0896(02)00451-0.