PSB-SB-1202
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| Identifiers | |
|---|---|
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| CAS Number | 1399049-60-5 |
| PubChem (CID) | 70677953 |
| Chemical and physical data | |
| Formula | C23H26O4 |
| Molar mass | 366.45 |
| 3D model (Jmol) | Interactive image |
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PSB-SB-1202 is a coumarin derivative which is an agonist at the cannabinoid receptors CB1 and CB2, with a CB1 Ki of 32nM and a CB2 Ki of 49nM.[1] It is also a weak antagonist at the related receptor GPR55, with an IC50 of 6350nM, but has no significant affinity for GPR18.[2]
See also
References
- ↑ Rempel V, Volz N, Hinz S, Karcz T, Meliciani I, Nieger M, Wenzel W, Bräse S, Müller CE. 7-Alkyl-3-benzylcoumarins: a versatile scaffold for the development of potent and selective cannabinoid receptor agonists and antagonists. Journal of Medicinal Chemistry. 2012 Sep 27;55(18):7967-77. PMID 22916707
- ↑ Rempel, V.; Volz, N.; Gläser, F.; Nieger, M.; Bräse, S.; Müller, C. E. (2013). "Antagonists for the orphan G protein-coupled receptor GPR55 based on a coumarin scaffold". Journal of Medicinal Chemistry. 56 (11): 130516144836005. doi:10.1021/jm4005175. PMID 23679955.
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