KRT33A

KRT33A
Identifiers
Aliases	KRT33A, HA3I, Ha-3I, K33A, KRTHA3A, Krt1-3, hHa3-I, keratin 33A
External IDs	HomoloGene: 135742 GeneCards: KRT33A
Orthologs
Species	Human	Mouse
Entrez	3883	n/a
Ensembl	n/a	n/a
UniProt	O76009	n/a
RefSeq (mRNA)	NM_004138	n/a
RefSeq (protein)	NP_004129.2	n/a
Location (UCSC)	Chr 17: 41.35 – 41.35 Mb	n/a
PubMed search	[1]	n/a
Wikidata

View/Edit Human

Keratin, type I cuticular Ha3-I is a protein that in humans is encoded by the KRT33A gene.^[2][3][4]

The protein encoded by this gene is a member of the keratin gene family. It is one of the type I hair keratin genes which are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. There are two isoforms of this protein, encoded by two separate genes, KRTHA3A and KRTHA3B.^[4]

References

1. "Human PubMed Reference:".
2. Rogers MA, Schweizer J, Kreig T, Winter H (Nov 1995). "A novel human type I hair keratin gene: evidence for two keratin hHa3 isoforms". Mol Biol Rep. 20 (3): 155–61. doi:10.1007/BF00990548. PMID 7565656.
3. Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
4. "Entrez Gene: KRT33A keratin 33A".

Further reading

• Yu J, Yu DW, Checkla DM, et al. (1993). "Human hair keratins". J. Invest. Dermatol. 101 (1 Suppl): 56S–59S. doi:10.1111/1523-1747.ep12362635. PMID 7686952.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Rogers MA, Winter H, Langbein L, et al. (2005). "The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain". Differentiation. 72 (9–10): 527–40. doi:10.1111/j.1432-0436.2004.07209006.x. PMID 15617563.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Langbein L, Rogers MA, Winter H, et al. (1999). "The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle". J. Biol. Chem. 274 (28): 19874–84. doi:10.1074/jbc.274.28.19874. PMID 10391933.
• Rogers MA, Winter H, Wolf C, et al. (1998). "Characterization of a 190-kilobase pair domain of human type I hair keratin genes". J. Biol. Chem. 273 (41): 26683–91. doi:10.1074/jbc.273.41.26683. PMID 9756910.