PD-128,907

PD-128,907

Identifiers
IUPAC name (4aR,10bR)-3,4a,4,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano-[4,3-b]-1,4-oxazin-9-ol
CAS Number	123594-64-9 300576-59-4 (hydrochloride)
PubChem (CID)	5311346
ChemSpider	23180492
ChEMBL	CHEMBL94015
Chemical and physical data
Formula	C14H19NO3
Molar mass	249.305 g/mol
3D model (Jmol)	Interactive image
SMILES c23cc(O)ccc3OCC1C2OCCN1CCC
InChI InChI=1S/C14H19NO3/c1-2-5-15-9-17-7-12-11-6-10(16)3-4-14(11)18-8-13(12)15/h3-4,6,12-13,16H,2,5,7-9H2,1H3/t12-,13-/m1/s1 Key:ZFSOBPVEIKTNQS-CHWSQXEVSA-N
(what is this?)  (verify)

PD-128,907 is a drug used in scientific research which acts as a potent and selective agonist for the dopamine D₂ and D₃ receptors.^[1] It is used for studying the role of these receptors in the brain, in roles such as inhibitory autoreceptors that act to limit further dopamine release,^[2] as well as release of other neurotransmitters.^[3] In animal studies it has been shown to reduce toxicity from cocaine overdose.^[4][5]

See also

• 7-OH-DPAT
• PF-219,061
• PF-592,379

References

1. DeWald HA, Heffner TG, Jaen JC, Lustgarten DM, McPhail AT, Meltzer LT, Pugsley TA, Wise LD. Synthesis and dopamine agonist properties of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol and its enantiomers. Journal of Medicinal Chemistry. 1990 Jan;33(1):445-50. PMID 1967318
2. Koeltzow TE, Xu M, Cooper DC, Hu XT, Tonegawa S, Wolf ME, White FJ. Alterations in dopamine release but not dopamine autoreceptor function in dopamine D3 receptor mutant mice. Journal of Neuroscience. 1998 Mar 15;18(6):2231-8. PMID 9482807
3. Chen G, Kittler JT, Moss SJ, Yan Z. Dopamine D3 receptors regulate GABAA receptor function through a phospho-dependent endocytosis mechanism in nucleus accumbens. Journal of Neuroscience. 2006 Mar 1;26(9):2513-21. PMID 16510729
4. Witkin JM, Dijkstra D, Levant B, Akunne HC, Zapata A, Peters S, Shannon HE, Gasior M. Protection against cocaine toxicity in mice by the dopamine D3/D2 agonist R-(+)-trans-3,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol [(+)-PD 128,907]. Journal of Pharmacology and Experimental Therapeutics. 2004 Mar;308(3):957-64. PMID 14711932
5. Witkin JM, Levant B, Zapata A, Kaminski R, Gasior M. The dopamine D3/D2 agonist (+)-PD-128,907 [(R-(+)-trans-3,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol)] protects against acute and cocaine-kindled seizures in mice: further evidence for the involvement of D3 receptors. Journal of Pharmacology and Experimental Therapeutics. 2008 Sep;326(3):930-8. PMID 18566292