Polmacoxib

Polmacoxib

Clinical data
Trade names	Acelex
Identifiers
IUPAC name 4-(3-(3-Fluorophenyl)-5,5-dimethyl-4-oxo-4,5-dihydrofuran-2-yl)-benzenesulfonamide
Synonyms	CG100649
CAS Number	301692-76-2
PubChem (CID)	9841854
ChemSpider	8017569
UNII	IJ34D6YPAO
ChEMBL	CHEMBL166863
Chemical and physical data
Formula	C12H16FNO4S
Molar mass	361.3914 g/mol
3D model (Jmol)	Interactive image
SMILES CC1(C(=O)C(=C(O1)C2=CC=C(C=C2)S(=O)(=O)N)C3=CC(=CC=C3)F)C
InChI InChI=1S/C18H16FNO4S/c1-18(2)17(21)15(12-4-3-5-13(19)10-12)16(24-18)11-6-8-14(9-7-11)25(20,22)23/h3-10H,1-2H3,(H2,20,22,23) Key:IJWPAFMIFNSIGD-UHFFFAOYSA-N

Polmacoxib (Acelex) is a nonsteroidal anti-inflammatory drug (NSAID) used to treat osteoarthritis. It was developed as CG100649 and approved for use in South Korea in February 2015.^[1] It inhibits the enzymes carbonic anhydrase and COX-2. A study in healthy volunteers showed drug effects on urinary prostaglandin metabolites for both CG100649 and celecoxib that suggest a similar cardiovascular risk profile.^[2] Further work by this group developed dose-exposure relationsships of CG100649 to guide clinical development strategies. ^[3]

See also

• Tilmacoxib
• Cimicoxib
• NS-398
• Celecoxib

References

1. "CrystalGenomics Receives MFDS Approval for Acelex® (Polmacoxib)". PR Newswire.
2. Skarke, C.; Alamuddin, N.; Lawson, J. A.; Cen, L.; Propert, K. J.; Fitzgerald, G. A. (2012). "Comparative impact on prostanoid biosynthesis of celecoxib and the novel nonsteroidal anti-inflammatory drug CG100649". Clinical Pharmacology & Therapeutics. 91 (6): 986–93. doi:10.1038/clpt.2012.3. PMC 3740579. PMID 22278334.
3. Hirankarn, S.; Barrett, J.S.; Alamuddin, N.; Fitzgerald, G. A.; Skarke, C. (2013). "GCG100649, A Novel Cyclooxygenase-2 Inhibitor, Exhibits a Drug Disposition Profile in Healthy Volunteers Compatible With High Affinity to Carbonic Anhydrase-I/II: Preliminary Dose–Exposure Relationships to Define Clinical Development Strategies". Clinical Pharmacology in Drug Development. 2 (4): 379–386. doi:10.1002/cpdd.47.