Meptazinol
 | |
| Clinical data | |
|---|---|
| AHFS/Drugs.com | International Drug Names |
| Dependence liability | Low |
| Routes of administration | Oral, IM, IV |
| ATC code | N02AX05 (WHO) |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Metabolism | The peak analgesic effect is seen within 30–60 minutes and lasts about 3–4 hours. |
| Biological half-life | Half-Life (1.4–4 hours). |
| Excretion | The drug is rapidly metabolised to the glucuronide, and mostly excreted in the urine. |
| Identifiers | |
| |
| CAS Number |
59263-76-2  |
| PubChem (CID) | 41049 |
| ChemSpider |
37469  |
| UNII |
18Y7S5JKZD |
| KEGG |
D08182 |
| ChEMBL |
CHEMBL314437 |
| ECHA InfoCard | 100.053.718 |
| Chemical and physical data | |
| Formula | C15H23NO |
| Molar mass | 233.34922 g/mol |
| 3D model (Jmol) | Interactive image |
| Chirality | Racemic mixture |
| |
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| (what is this?) (verify) | |
Meptazinol (trade name Meptid) is an opioid analgesic developed by Wyeth in the 1970s.[1] Indications for use in moderate to severe pain, most commonly used to treat pain in obstetrics (childbirth).
Meptazinol is a 3-phenylazpane derivative, whereas the other phenazepanes like ethoheptazine and proheptazine are 4-phenylazepanes.
A partial µ-opioid receptor agonist, its mixed agonist/antagonist activity affords it a lower risk of dependence and abuse than full µ agonists like morphine. Meptazinol exhibits not only a short onset of action, but also a shorter duration of action relative to other opioids such as morphine, pentazocine, or buprenorphine.[2]
References
- ↑ US patent 4197239, Cavalla JF, Shepherd RG, White AC, "Hexahydroazepine, Piperidine and Pyrrolidine Derivatives", issued 1980-04-08, assigned to Wyeth
- ↑ Holmes B, Ward A (1985). "Meptazinol. A Review of its Pharmacodynamic and Pharmacokinetic Properties and Therapeutic Efficacy". Drugs. 30 (4): 285–312. doi:10.2165/00003495-198530040-00001. PMID 2998723.
External links
- Meptazinol at the US National Library of Medicine Medical Subject Headings (MeSH)
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