CACNB3

CACNB3
Identifiers
Aliases	CACNB3, CAB3, CACNLB3, calcium voltage-gated channel auxiliary subunit beta 3
External IDs	MGI: 103307 HomoloGene: 20187 GeneCards: CACNB3
Gene ontology Molecular function • protein kinase binding • voltage-gated ion channel activity • voltage-gated calcium channel activity • high voltage-gated calcium channel activity • calcium channel activity Cellular component • apical plasma membrane • membrane • cytosol • plasma membrane • voltage-gated calcium channel complex • L-type voltage-gated calcium channel complex Biological process • membrane depolarization • regulation of ion transmembrane transport • ion transport • T cell receptor signaling pathway • regulation of voltage-gated calcium channel activity • neuromuscular junction development • calcium ion transmembrane transport • cardiac conduction • transport • calcium ion transport • regulation of membrane repolarization during action potential • calcium ion transport into cytosol • protein localization to plasma membrane • chemical synaptic transmission • calcium ion transmembrane transport via high voltage-gated calcium channel Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	784	12297
Ensembl	ENSG00000167535	ENSMUSG00000003352
UniProt	P54284	P54285
RefSeq (mRNA)	NM_000725 NM_001206915 NM_001206916 NM_001206917	NM_001044741 NM_001286226 NM_007581
RefSeq (protein)	NP_000716.2 NP_001193844.1 NP_001193845.1 NP_001193846.1	NP_031607.2
Location (UCSC)	Chr 12: 48.81 – 48.83 Mb	Chr 15: 98.63 – 98.64 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

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Voltage-dependent L-type calcium channel subunit beta-3 is a protein that in humans is encoded by the CACNB3 gene.^[3][4]

See also

• Voltage-dependent calcium channel

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Collin T, Lory P, Taviaux S, Courtieu C, Guilbault P, Berta P, Nargeot J (Apr 1994). "Cloning, chromosomal location and functional expression of the human voltage-dependent calcium-channel beta 3 subunit". Eur J Biochem. 220 (1): 257–62. doi:10.1111/j.1432-1033.1994.tb18621.x. PMID 8119293.
4. "Entrez Gene: CACNB3 calcium channel, voltage-dependent, beta 3 subunit".

Further reading

• Yamada Y, Masuda K, Li Q, et al. (1995). "The structures of the human calcium channel alpha 1 subunit (CACNL1A2) and beta subunit (CACNLB3) genes.". Genomics. 27 (2): 312–9. doi:10.1006/geno.1995.1048. PMID 7557998.
• Rosenfeld MR, Wong E, Dalmau J, et al. (1993). "Cloning and characterization of a Lambert-Eaton myasthenic syndrome antigen.". Ann. Neurol. 33 (1): 113–20. doi:10.1002/ana.410330126. PMID 8494331.
• Murakami M, Wissenbach U, Flockerzi V (1996). "Gene structure of the murine calcium channel beta3 subunit, cDNA and characterization of alternative splicing and transcription products.". Eur. J. Biochem. 236 (1): 138–43. doi:10.1111/j.1432-1033.1996.t01-1-00138.x. PMID 8617257.
• Scott VE, De Waard M, Liu H, et al. (1996). "Beta subunit heterogeneity in N-type Ca2+ channels.". J. Biol. Chem. 271 (6): 3207–12. doi:10.1074/jbc.271.6.3207. PMID 8621722.
• Bell DC, Butcher AJ, Berrow NS, et al. (2001). "Biophysical properties, pharmacology, and modulation of human, neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium currents.". J. Neurophysiol. 85 (2): 816–27. PMID 11160515.
• Colecraft HM, Alseikhan B, Takahashi SX, et al. (2002). "Novel functional properties of Ca(2+) channel beta subunits revealed by their expression in adult rat heart cells.". J. Physiol. (Lond.). 541 (Pt 2): 435–52. doi:10.1113/jphysiol.2002.018515. PMC 2290333. PMID 12042350.
• Murakami M, Fleischmann B, De Felipe C, et al. (2002). "Pain perception in mice lacking the beta3 subunit of voltage-activated calcium channels.". J. Biol. Chem. 277 (43): 40342–51. doi:10.1074/jbc.M203425200. PMID 12161429.
• Qin N, Yagel S, Momplaisir ML, et al. (2002). "Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit.". Mol. Pharmacol. 62 (3): 485–96. doi:10.1124/mol.62.3.485. PMID 12181424.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Chen YH, Li MH, Zhang Y, et al. (2004). "Structural basis of the alpha1-beta subunit interaction of voltage-gated Ca2+ channels.". Nature. 429 (6992): 675–80. doi:10.1038/nature02641. PMID 15170217.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Vendel AC, Terry MD, Striegel AR, et al. (2006). "Alternative splicing of the voltage-gated Ca2+ channel beta4 subunit creates a uniquely folded N-terminal protein binding domain with cell-specific expression in the cerebellar cortex.". J. Neurosci. 26 (10): 2635–44. doi:10.1523/JNEUROSCI.0067-06.2006. PMID 16525042.

External links

• CACNB3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)