CLIC5

CLIC5
Identifiers
Aliases	CLIC5, MST130, MSTP130, DFNB102, DFNB103, chloride intracellular channel 5
External IDs	MGI: 1917912 HomoloGene: 987 GeneCards: CLIC5
Gene ontology Molecular function • chloride channel activity • protein binding • voltage-gated ion channel activity • glutathione transferase activity Cellular component • cell cortex • microtubule organizing center • nucleus • cytoplasm • cytoskeleton • chloride channel complex • actin cytoskeleton • integral component of membrane • stereocilium bundle • membrane • extracellular exosome • stereocilium • Golgi apparatus Biological process • regulation of ion transmembrane transport • ion transport • sensory perception of sound • female pregnancy • diet induced thermogenesis • response to dietary excess • protein localization • auditory receptor cell stereocilium organization • glutathione metabolic process • neuromuscular process controlling balance • transport • chloride transport • chloride transmembrane transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	53405	224796
Ensembl	ENSG00000112782	ENSMUSG00000023959
UniProt	Q9NZA1 Q53G01 Q49AE1	Q8BXK9
RefSeq (mRNA)	NM_001114086 NM_001256023 NM_016929	NM_172621
RefSeq (protein)	NP_001107558.1 NP_001242952.1 NP_058625.2 NP_001107558.1 NP_058625.2 NP_001242952.1	NP_766209.1
Location (UCSC)	Chr 6: 45.9 – 46.08 Mb	Chr 17: 44.19 – 44.28 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Chloride intracellular channel protein 5 is a protein that in humans is encoded by the CLIC5 gene.^[3][4]

Function

Chloride intracellular channels are involved in chloride ion transport within various subcellular compartments. CLIC5 specifically associates with the cytoskeleton of placenta microvilli.^[4] CLIC5 can form ion channel in bilayers and is regulated by actin.

See also

• Chloride channel

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Berryman M, Bretscher A (Aug 2000). "Identification of a Novel Member of the Chloride Intracellular Channel Gene Family (CLIC5) That Associates with the Actin Cytoskeleton of Placental Microvilli". Mol Biol Cell. 11 (5): 1509–21. doi:10.1091/mbc.11.5.1509. PMC 14863. PMID 10793131.
4. "Entrez Gene: CLIC5 chloride intracellular channel 5".

Further reading

• Singh H (2010). "Two decades with dimorphic Chloride Intracellular Channels (CLICs)". FEBS Letters. 584 (10): 2112–21. doi:10.1016/j.febslet.2010.03.013. PMID 20226783.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Shanks RA, Larocca MC, Berryman M, et al. (2002). "AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member". J. Biol. Chem. 277 (43): 40973–80. doi:10.1074/jbc.M112277200. PMID 12163479.
• Suzuki T, Morita R, Sugimoto Y, et al. (2002). "Identification and mutational analysis of candidate genes for juvenile myoclonic epilepsy on 6p11-p12: LRRC1, GCLC, KIAA0057 and CLIC5". Epilepsy Res. 50 (3): 265–75. doi:10.1016/S0920-1211(02)00052-9. PMID 12200217.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Berryman M, Bruno J, Price J, Edwards JC (2004). "CLIC-5A functions as a chloride channel in vitro and associates with the cortical actin cytoskeleton in vitro and in vivo". J. Biol. Chem. 279 (33): 34794–801. doi:10.1074/jbc.M402835200. PMID 15184393.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Gonzalez A, Ciobanu D, Sayers M, et al. (2007). "Gene transcript amplification from cell lysates in continuous-flow microfluidic devices". Biomedical microdevices. 9 (5): 729–36. doi:10.1007/s10544-007-9083-1. PMID 17492382.
• Singh H, Cousin MA, Ashley RH (2007). "Functional reconstitution of mammalian 'chloride intracellular channels' CLIC1, CLIC4 and CLIC5 reveals differential regulation by cytoskeletal actin". FEBS J. 274 (24): 6306–6316. doi:10.1111/j.1742-4658.2007.06145.x. PMID 18028448.

External links

• CLIC5 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.