KCNK5

KCNK5
Identifiers
Aliases KCNK5, K2p5.1, TASK-2, TASK2, KCNK5b, potassium two pore domain channel subfamily K member 5
External IDs MGI: 1336175 HomoloGene: 2773 GeneCards: KCNK5
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

8645

16529

Ensembl

ENSG00000164626

ENSMUSG00000023243

UniProt

O95279

n/a

RefSeq (mRNA)

NM_003740

NM_021542

RefSeq (protein)

NP_003731.1

n/a

Location (UCSC) Chr 6: 39.19 – 39.23 Mb Chr 14: 20.14 – 20.18 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Potassium channel subfamily K member 5 is a protein that in humans is encoded by the KCNK5 gene.[3][4][5]

This gene encodes K2P5.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport.[5]

See also

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Reyes R, Duprat F, Lesage F, Fink M, Salinas M, Farman N, Lazdunski M (Dec 1998). "Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney". J Biol Chem. 273 (47): 30863–9. doi:10.1074/jbc.273.47.30863. PMID 9812978.
  4. Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106.
  5. 1 2 "Entrez Gene: KCNK5 potassium channel, subfamily K, member 5".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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