KCNK7

KCNK7
Identifiers
Aliases KCNK7, K2p7.1, TWIK3, potassium two pore domain channel subfamily K member 7
External IDs MGI: 1341841 HomoloGene: 43131 GeneCards: KCNK7
Orthologs
Species Human Mouse
Entrez

10089

16530

Ensembl

ENSG00000173338

ENSMUSG00000024936

UniProt

Q9Y2U2

Q9Z2T1

RefSeq (mRNA)

NM_033456
NM_005714
NM_033347
NM_033348
NM_033455

NM_001004138
NM_010609

RefSeq (protein)

NP_005705.1
NP_203133.1
NP_203134.1
NP_258416.1

NP_034739.2

Location (UCSC) Chr 11: 65.59 – 65.6 Mb Chr 19: 5.7 – 5.71 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Potassium channel, subfamily K, member 7, also known as KCNK7 or K2P7.1 is a protein which in humans is encoded by the KCNK7 gene. K2P7.1 is a potassium channel containing two pore-forming P domains.[3][4][5] Multiple transcript variants encoding different isoforms have been found for this gene.[6]

Function

This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel; It may require other non-pore-forming proteins for activity.[6]

See also

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Salinas M, Reyes R, Lesage F, Fosset M, Heurteaux C, Romey G, Lazdunski M (April 1999). "Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure". J. Biol. Chem. 274 (17): 11751–60. doi:10.1074/jbc.274.17.11751. PMID 10206991.
  4. Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (March 2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078.
  5. Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol. Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106.
  6. 1 2 "Entrez Gene: potassium channel".

Further reading

External links


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