KCNA6

KCNA6
Identifiers
Aliases	KCNA6, HBK2, KV1.6, PPP1R96, potassium voltage-gated channel subfamily A member 6
External IDs	MGI: 96663 HomoloGene: 1684 GeneCards: KCNA6
Targeted by Drug
tetraethylammonium[1]
Gene ontology Molecular function • voltage-gated potassium channel activity • ion channel activity • potassium channel activity • delayed rectifier potassium channel activity • voltage-gated ion channel activity Cellular component • axon terminus • integral component of membrane • voltage-gated potassium channel complex • axon • plasma membrane • potassium channel complex • integral component of plasma membrane • membrane Biological process • potassium ion transport • regulation of ion transmembrane transport • protein homooligomerization • ion transport • transmembrane transport • potassium ion transmembrane transport • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3742	16494
Ensembl	n/a	ENSMUSG00000038077
UniProt	P17658	Q61923
RefSeq (mRNA)	NM_002235	NM_013568
RefSeq (protein)	NP_002226.1	NP_038596.1
Location (UCSC)	Chr 12: 4.81 – 4.81 Mb	Chr 6: 126.71 – 126.74 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

Potassium voltage-gated channel subfamily A member 6 also known as K_v1.6 is a protein that in humans is encoded by the KCNA6 gene.^[4][4] The protein encoded by this gene is a voltage-gated potassium channel subunit.

References

1. "Drugs that physically interact with Potassium voltage-gated channel subfamily A member 6 view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104.

Further reading

• Albrecht B, Weber K, Pongs O (1995). "Characterization of a voltage-activated K-channel gene cluster on human chromosome 12p13.". Recept. Channels. 3 (3): 213–20. PMID 8821794.
• Tan KM, Lennon VA, Klein CJ, et al. (2008). "Clinical spectrum of voltage-gated potassium channel autoimmunity.". Neurology. 70 (20): 1883–90. doi:10.1212/01.wnl.0000312275.04260.a0. PMID 18474843.
• Grupe A, Schröter KH, Ruppersberg JP, et al. (1990). "Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family.". EMBO J. 9 (6): 1749–56. PMC 551878. PMID 2347305.
• Yusifov T, Savalli N, Gandhi CS, et al. (2008). "The RCK2 domain of the human BKCa channel is a calcium sensor.". Proc. Natl. Acad. Sci. U.S.A. 105 (1): 376–81. Bibcode:2008PNAS..105..376Y. doi:10.1073/pnas.0705261105. PMC 2224220. PMID 18162557.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• Kv1.6 Potassium Channel at the US National Library of Medicine Medical Subject Headings (MeSH)
• KCNA6 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)