Pitrazepin

Pitrazepin

Clinical data
Pregnancy category	?
Routes of administration	?
ATC code	none
Legal status
Legal status	Uncontrolled
Identifiers
IUPAC name 3-(piperazin-1-yl)-9H-dibenzo[c,f][1,2,4]triazolo[4,3-a]azepine
CAS Number	90685-01-1
PubChem (CID)	146222
ChemSpider	128982
Chemical and physical data
Formula	C19H19N5
Molar mass	317.39 g/mol
3D model (Jmol)	Interactive image
SMILES n4nc(N1CCNCC1)n5c2ccccc2Cc3ccccc3c45

Pitrazepin is a competitive GABA_A and glycine receptor antagonist.^[1][2][3] It has been used to study insect and snail nervous systems in scientific research.^{[4][5][6][7][8][9]}

See also

• Bicuculline
• Strychnine

References

1. Gähwiler BH, Maurer R, Wüthrich HJ (April 1984). "Pitrazepin, a novel GABAA antagonist". Neuroscience Letters. 45 (3): 311–6. doi:10.1016/0304-3940(84)90244-1. PMID 6328380.
2. Braestrup C, Nielsen M (November 1985). "Interaction of pitrazepin with the GABA/benzodiazepine receptor complex and with glycine receptors". European Journal of Pharmacology. 118 (1-2): 115–21. doi:10.1016/0014-2999(85)90669-7. PMID 3002806.
3. Curtis DR, Gynther BD (November 1986). "Pitrazepin: a central glycine and GABA antagonist". European Journal of Pharmacology. 131 (2-3): 311–3. doi:10.1016/0014-2999(86)90590-X. PMID 3816960.
4. Anthony NM, Harrison JB, Sattelle DB (1993). "GABA receptor molecules of insects". Exs. 63: 172–209. doi:10.1007/978-3-0348-7265-2_8. PMID 7678525.
5. Sattelle DB, Pinnock RD, Wafford KA, David JA (January 1988). "GABA receptors on the cell-body membrane of an identified insect motor neuron". Proceedings of the Royal Society B. 232 (1269): 443–56. doi:10.1098/rspb.1988.0006. PMID 2451252.
6. Murphy VF, Wann KT (November 1988). "The action of GABA receptor agonists and antagonists on muscle membrane conductance in Schistocerca gregaria". British Journal of Pharmacology. 95 (3): 713–22. doi:10.1111/j.1476-5381.1988.tb11697.x. PMC 1854212. PMID 2850061.
7. Zhang W, Han XY, Wong SM, Takeuchi H (January 1997). "Pharmacologic characteristics of excitatory gamma-amino-butyric acid (GABA) receptors in a snail neuron". General Pharmacology. 28 (1): 45–53. doi:10.1016/S0306-3623(96)00152-8. PMID 9112076.
8. Kim KH, Takeuchi H (June 1990). "Pharmacological characteristics of two different types of inhibitory GABA receptors on Achatina fulica neurones". European Journal of Pharmacology. 182 (1): 49–62. doi:10.1016/0014-2999(90)90492-O. PMID 2169426.
9. Takeuchi H (September 1992). "Sensitivities of Achatina giant neurones to putative amino acid neurotransmitters". Comparative Biochemistry and Physiology C. 103 (1): 1–12. doi:10.1016/0742-8413(92)90219-w. PMID 1360362.