Atiprosin
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Clinical data | |
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Routes of administration | Oral |
ATC code | none |
Legal status | |
Legal status |
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Identifiers | |
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CAS Number |
89303-63-9 ![]() |
PubChem (CID) | 71770 |
ChemSpider |
64808 ![]() |
UNII |
ALS52889WF ![]() |
ChEMBL |
CHEMBL2111172 ![]() |
Chemical and physical data | |
Formula | C20H29N3 |
Molar mass | 311.46 g/mol |
3D model (Jmol) | Interactive image |
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Atiprosin (AY-28,228) is an antihypertensive agent which acts as a selective α1-adrenergic receptor antagonist.[1][2][3][4] It also possesses some antihistamine activity, though it is some 15-fold weaker in this regard than as an alpha blocker.[3] It was never marketed.[1]
See also
References
- 1 2 David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9.
- ↑ Jirkovsky I, Santroch G, Baudy R, Oshiro G (February 1987). "Octahydropyrazino[2',3':3,4]pyrido[1,2-a]indoles. A new class of potent antihypertensive agents". Journal of Medicinal Chemistry. 30 (2): 388–94. doi:10.1021/jm00385a022. PMID 3806618.
- 1 2 Grimes D, Rimele TJ, Henry DE, et al. (September 1987). "In vitro isolated tissue studies with atiprosin (AY-28,228): a new antihypertensive compound". Journal of Cardiovascular Pharmacology. 10 (3): 249–58. doi:10.1097/00005344-198709000-00001. PMID 2444771.
- ↑ Oshiro G, Wojdan A, Klein M, Metcalf G (September 1987). "Antihypertensive and hypotensive actions of atiprosin (AY-28,228) in rats, dogs, and monkeys". Journal of Cardiovascular Pharmacology. 10 (3): 341–9. doi:10.1097/00005344-198709000-00014. PMID 2444784.
Sympatholytics (antagonize α-adrenergic vasoconstriction) |
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Other antagonists |
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Receptor (ligands) |
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Transporter (inhibitors) |
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Enzyme (inhibitors) |
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Others |
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Classes |
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Antidepressants (TCAs and TeCAs) |
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Antihistamines |
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Antipsychotics |
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Anticonvulsants | |
Others |
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