DADLE
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| Names | |
|---|---|
| IUPAC name
(2R)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid | |
| Other names
• [D-Ala2, D-Leu5]-Enkephalin • L-Tyrosyl-D-alanylglycyl-L-phenylalanyl-D-Leucine • N-(N-(N-(N-L-tyrosyl-D-alanyl)glycyl)-L-phenylalanyl)-D-Leucine • Tyr-D-Ala-Gly-Phe-D-Leu-OH | |
| Identifiers | |
63631-40-3  | |
| 3D model (Jmol) | Interactive image |
| ChemSpider | 5292936  |
| ECHA InfoCard | 100.059.337 |
| PubChem | 6917707 |
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| Properties | |
| C29H39N5O7 | |
| Molar mass | 569.66 g·mol−1 |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| verify (what is ?) | |
| Infobox references | |
DADLE ([D-Ala2, D-Leu5]-Enkephalin) is a synthetic opioid peptide with analgesic properties. Although it is often considered a selective delta opioid receptor agonist, it also binds to the μ1 subtype of mu opioid receptors.
Treatment with DADLE results in transient depression of mean arterial blood pressure and heart rate.[1][2]
Its peptide sequence is Tyr-D-Ala-Gly-Phe-D-Leu.
References
This article is issued from Wikipedia - version of the 9/27/2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.