U-50488

U-50488

Identifiers
IUPAC name 2-(3,4-dichlorophenyl)-N-methyl-N-[(1R,2R)-2-pyrrolidin-1-ylcyclohexyl]acetamide
CAS Number	67198-13-4
PubChem (CID)	3036289
IUPHAR/BPS	1652
ChEBI	CHEBI:73358
ChEMBL	CHEMBL441765
Chemical and physical data
Formula	C19H26Cl2N2O
Molar mass	369.329 g/mol
3D model (Jmol)	Interactive image
SMILES CN([C@@H]1CCCC[C@H]1N2CCCC2)C(=O)CC3=CC(=C(C=C3)Cl)Cl
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U-50488 is a drug which acts as a highly selective κ-opioid agonist, but without any μ-opioid antagonist effects.^[1] It has analgesic, diuretic and antitussive effects,^[2] and reverses the memory impairment produced by anticholinergic drugs.^[3] U-50488 was one of the first selective kappa agonists invented and research on its derivatives has led to the development of a large family of related compounds.^[4][5]

See also

• U-47700
• U-69,593

References

1. Von Voigtlander, PF; Lewis, RA (1982). "U-50,488, a selective kappa opioid agonist: comparison to other reputed kappa agonists". Progress in neuro-psychopharmacology & biological psychiatry. 6 (4–6): 467–70. doi:10.1016/S0278-5846(82)80130-9. PMID 6298890.
2. Kamei, J (1996). "Role of opioidergic and serotonergic mechanisms in cough and antitussives". Pulmonary pharmacology. 9 (5–6): 349–56. doi:10.1006/pulp.1996.0046. PMID 9232674.
3. Hiramatsu, M; Kameyama, T (1998). "Roles of kappa-opioid receptor agonists in learning and memory impairment in animal models". Methods and findings in experimental and clinical pharmacology. 20 (7): 595–9. doi:10.1358/mf.1998.20.7.485724. PMID 9819804.
4. Szmuszkovicz, J (1999). "U-50,488 and the kappa receptor: a personalized account covering the period 1973 to 1990". Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques. 52: 167–95. PMID 10396128.
5. Szmuszkovicz, J (1999). "U-50,488 and the kappa receptor. Part II: 1991-1998". Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques. 53: 1–51. PMID 10616295.