C-8813

C-8813

Identifiers
IUPAC name trans-4-(p-Bromophenyl)-4-(dimethylamino)-1-(2-(thiophen-2-yl)ethyl)cyclohexanol
CAS Number	616898-54-5
PubChem (CID)	11058633
Chemical and physical data
Formula	C20H26BrNOS
Molar mass	408.394 g/mol
3D model (Jmol)	Interactive image
SMILES BrC1=CC=C([C@@]2(CC[C@](CC2)(CCC3=CC=CS3)O)N(C)C)C=C1
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C-8813 (thiobromadol) is a potent μ-opioid receptor agonist with a distinctive chemical structure which is not closely related to other established families of opioid drugs. The trans-isomer was found to be around 591 times more potent than morphine in animal studies.^[1] The same study assigned a potency of 504 times that of morphine to the related compound BDPC.

C-8813 is claimed to be similarly potent at the δ-opioid receptor, which antagonizes the mu depression of breathing, presumably making the drug safer.^[1]

C-8813 has never been used in humans.

See also

• BDPC
• Ciramadol
• Faxeladol
• Profadol
• Tapentadol
• Tramadol

References

1. Liu, Z. H.; Jin, W. Q.; Dai, Q. Y.; Chen, X. J.; Zhang, H. P.; Chi, Z. Q. (2003). "Opioid activity of C8813, a novel and potent opioid analgesic". Life Sciences. 73 (2): 233–241. doi:10.1016/S0024-3205(03)00263-7. PMID 12738037.