CD1

For the album by Throbbing Gristle, see CD1 (album).

CD1a molecule
Identifiers
Symbol	CD1A
Alt. symbols	CD1
Entrez	909
HUGO	1634
OMIM	188370
RefSeq	NM_001763
UniProt	P06126
Other data
Locus	Chr. 1 q22-q23

CD1b molecule
Identifiers
Symbol	CD1B
Alt. symbols	CD1
Entrez	910
HUGO	1635
OMIM	188360
RefSeq	NM_001764
UniProt	P29016
Other data
Locus	Chr. 1 q22-q23

CD1c molecule
Identifiers
Symbol	CD1C
Alt. symbols	CD1
Entrez	911
HUGO	1636
OMIM	188340
RefSeq	NM_001765
UniProt	P29017
Other data
Locus	Chr. 1 q22-q23

CD1d molecule
Identifiers
Symbol	CD1D
Entrez	912
HUGO	1637
OMIM	188410
RefSeq	NM_001766
UniProt	P15813
Other data
Locus	Chr. 1 q22-q23

CD1e molecule
Identifiers
Symbol	CD1E
Entrez	913
HUGO	1638
OMIM	188411
RefSeq	NM_030893
UniProt	P15812
Other data
Locus	Chr. 1 q22-q23

CD1 (cluster of differentiation 1) is a family of glycoproteins expressed on the surface of various human antigen-presenting cells. They are related to the class I MHC molecules, and are involved in the presentation of lipid antigens to T cells. However their precise function is unknown.^[1]

Types

CD1 glycoproteins can be classified primarily into two groups which differ in their lipid anchoring.^[2]

CD1a, CD1b and CD1c (group 1 CD1 molecules) are expressed on cells specialized for antigen presentation.^[3]
CD1d (group 2 CD1) is expressed in a wider variety of cells.

CD1e is an intermediate form, expressed intracellularly, the role of which is currently unclear.^[4]

In humans

Group 1

Group 1 CD1 molecules have been shown to present foreign lipid antigens, and specifically a number of mycobacterial cell wall components, to CD1-specific T cells.

Group 2

The natural antigens of group 2 CD1 are not well-characterized, but a synthetic glycolipid, alpha-galactosylceramide, originally isolated from a compound found in a marine sponge, has strong biologic activity.

Group 2 CD1 molecules activate a group of T cells, known as Natural killer T cells because of their expression of NK surface markers such as CD161. Natural Killer T (NKT) cells are activated by CD1d-presented antigens, and rapidly produce Th1 and Th2 cytokines, typically represented by interferon-gamma and IL-4 production.

The group 2 (CD1d) ligand alpha-galactosylceramide is currently in phase I clinical trials for the treatment of advanced non-hematologic cancers.

Diagnostic relevance

CD1 antigens are expressed on cortical thymocytes, but not on mature T cells. This often remains true in neoplastic cells from these populations, so that the presence of CD1 antigens can be used in diagnostic immunohistochemistry to identify some thymomas and malignancies arising from T cell precursors. CD1a, in particular, is a specific marker for Langerhans cells, and can therefore also be used in the diagnosis of Langerhans cell histiocytosis. Other conditions that may show CD1 positivity include myeloid leukaemia and some B cell lymphomas.^[5]

In cows and mice

Mice lack the group 1 CD1 molecules, and instead have 2 copies of CD1d. Thus, mice have been used extensively to characterize the role of CD1d and CD1d-dependent NKT cells in a variety of disease models.

It has recently been shown that cows lack the group 2 CD1 molecules, and have an expanded set of group 1 CD1 molecules.^[6] Because of this and the fact that cows are a natural host of Mycobacterium bovis, a pathogen in humans as well, it is hoped that studying cows will yield insights into the group 1 CD1 antigen-presenting system.

References

↑ Porcelli S, Brenner MB, Greenstein JL, Balk SP, Terhorst C, Bleicher PA (1989). "Recognition of cluster of differentiation 1 antigens by human CD4-CD8-cytolytic T lymphocytes". Nature. 341 (6241): 447–50. doi:10.1038/341447a0. PMID 2477705.
↑ Zajonc DM, Wilson IA (2007). "Architecture of CD1 proteins". Curr. Top. Microbiol. Immunol. 314: 27–50. doi:10.1007/978-3-540-69511-0_2. PMID 17593656.
↑ Sköld M, Behar SM (2005). "The role of group 1 and group 2 CD1-restricted T cells in microbial immunity". Microbes Infect. 7 (3): 544–51. doi:10.1016/j.micinf.2004.12.012. PMID 15777730.
↑ Angenieux C, Salamero J, Fricker D, Cazenave JP, Goud B, Hanau D, de La Salle H (2000). "Characterization of CD1e, a third type of CD1 molecule expressed in dendritic cells". J. Biol. Chem. 275 (48): 37757–64. doi:10.1074/jbc.M007082200. PMID 10948205.
↑ Kumarasen C, Anthony S-Y L (2003). Manual of diagnostic antibodies for immunohistology. London: Greenwich Medical Media. pp. 59–60. ISBN 1-84110-100-1.
↑ Van Rhijn I, Koets AP, Im JS, Piebes D, Reddington F, Besra GS, Porcelli SA, van Eden W, Rutten VP (2006). "The bovine CD1 family contains group 1 CD1 proteins, but no functional CD1d". J. Immunol. 176 (8): 4888–93. doi:10.4049/jimmunol.176.8.4888. PMID 16585584.

External links

CD1 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
Mouse CD Antigen Chart
Human CD Antigen Chart

Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50

51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100

101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150

151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200

201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249

251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299

301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

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