LILRB2

LOC107987425
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2DYP, 2GW5, 4LLA
Identifiers
Aliases	LOC107987425, CD85D, ILT-4, ILT4, LIR-2, LIR2, MIR-10, MIR10, LILRB2
External IDs	HomoloGene: 136797 GeneCards: LOC107987425
Gene ontology Molecular function • inhibitory MHC class I receptor activity • MHC class Ib protein binding • protein phosphatase 1 binding • protein binding • MHC class I protein binding • cell adhesion molecule binding • receptor activity Cellular component • cytoplasm • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • extracellular space • cell surface Biological process • adaptive immune response • Fc receptor mediated inhibitory signaling pathway • positive regulation of tolerance induction • immune system process • positive regulation of regulatory T cell differentiation • heterotypic cell-cell adhesion • cell-cell signaling • regulation of dendritic cell differentiation • positive regulation of T cell tolerance induction • cellular defense response • cell surface receptor signaling pathway • negative regulation of T cell proliferation • negative regulation of immune response • immune response • positive regulation of T cell proliferation • negative regulation of calcium ion transport • positive regulation of interleukin-6 production • regulation of immune response • cellular response to lipopolysaccharide • immune response-inhibiting cell surface receptor signaling pathway • signal transduction • negative regulation of antigen processing and presentation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	107987425	n/a
Ensembl	n/a	n/a
UniProt	Q8N423	n/a
RefSeq (mRNA)	XM_006726278 XM_006726280 XM_011547050 XM_011547051 XM_011547058	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	Chr 19: 54.22 – 54.22 Mb	n/a
PubMed search	[1]	n/a
Wikidata

View/Edit Human

Leukocyte immunoglobulin-like receptor subfamily B member 2 is a protein that in humans is encoded by the LILRB2 gene.^[2][3][4]

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.^[4]

Interactions

LILRB2 has been shown to interact with PTPN6.^[5][6]

See also

• Cluster of differentiation

References

1. "Human PubMed Reference:".
2. Cella M, Dohring C, Samaridis J, Dessing M, Brockhaus M, Lanzavecchia A, Colonna M (Jun 1997). "A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing". J Exp Med. 185 (10): 1743–51. doi:10.1084/jem.185.10.1743. PMC 2196312. PMID 9151699.
3. Samaridis J, Colonna M (Apr 1997). "Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways". Eur J Immunol. 27 (3): 660–5. doi:10.1002/eji.1830270313. PMID 9079806.
4. "Entrez Gene: LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2".
5. Fanger, N A; Cosman D; Peterson L; Braddy S C; Maliszewski C R; Borges L (Nov 1998). "The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes". Eur. J. Immunol. GERMANY. 28 (11): 3423–34. doi:10.1002/(SICI)1521-4141(199811)28:11<3423::AID-IMMU3423>3.0.CO;2-2. ISSN 0014-2980. PMID 9842885.
6. Colonna, M; Samaridis J; Cella M; Angman L; Allen R L; O'Callaghan C A; Dunbar R; Ogg G S; Cerundolo V; Rolink A (Apr 1998). "Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules". J. Immunol. UNITED STATES. 160 (7): 3096–100. ISSN 0022-1767. PMID 9531263.

Further reading

• Suciu-Foca N, Cortesini R (2007). "Central role of ILT3 in the T suppressor cell cascade.". Cell. Immunol. 248 (1): 59–67. doi:10.1016/j.cellimm.2007.01.013. PMID 17923119.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Wagtmann N, Rojo S, Eichler E, et al. (1997). "A new human gene complex encoding the killer cell inhibitory receptors and related monocyte/macrophage receptors". Curr. Biol. 7 (8): 615–8. doi:10.1016/S0960-9822(06)00263-6. PMID 9259559.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Colonna M, Navarro F, Bellón T, et al. (1997). "A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells". J. Exp. Med. 186 (11): 1809–18. doi:10.1084/jem.186.11.1809. PMC 2199153. PMID 9382880.
• Colonna M, Samaridis J, Cella M, et al. (1998). "Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules". J. Immunol. 160 (7): 3096–100. PMID 9531263.
• Borges L, Hsu ML, Fanger N, et al. (1998). "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules". J. Immunol. 159 (11): 5192–6. PMID 9548455.
• Fanger NA, Cosman D, Peterson L, et al. (1998). "The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes". Eur. J. Immunol. 28 (11): 3423–34. doi:10.1002/(SICI)1521-4141(199811)28:11<3423::AID-IMMU3423>3.0.CO;2-2. PMID 9842885.
• Allan DS, Colonna M, Lanier LL, et al. (1999). "Tetrameric complexes of human histocompatibility leukocyte antigen (HLA)-G bind to peripheral blood myelomonocytic cells". J. Exp. Med. 189 (7): 1149–56. doi:10.1084/jem.189.7.1149. PMC 2193000. PMID 10190906.
• Lepin EJ, Bastin JM, Allan DS, et al. (2001). "Functional characterization of HLA-F and binding of HLA-F tetramers to ILT2 and ILT4 receptors". Eur. J. Immunol. 30 (12): 3552–61. doi:10.1002/1521-4141(200012)30:12<3552::AID-IMMU3552>3.0.CO;2-L. PMID 11169396.
• Young NT, Canavez F, Uhrberg M, et al. (2001). "Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex". Immunogenetics. 53 (4): 270–8. doi:10.1007/s002510100332. PMID 11491530.
• Chang CC, Ciubotariu R, Manavalan JS, et al. (2002). "Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4". Nat. Immunol. 3 (3): 237–43. doi:10.1038/ni760. PMID 11875462.
• Willcox BE, Thomas LM, Chapman TL, et al. (2003). "Crystal structure of LIR-2 (ILT4) at 1.8 A: differences from LIR-1 (ILT2) in regions implicated in the binding of the Human Cytomegalovirus class I MHC homolog UL18". BMC Struct. Biol. 2: 6. doi:10.1186/1472-6807-2-6. PMC 130215. PMID 12390682.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Shiroishi M, Tsumoto K, Amano K, et al. (2003). "Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G". Proc. Natl. Acad. Sci. U.S.A. 100 (15): 8856–61. doi:10.1073/pnas.1431057100. PMC 166403. PMID 12853576.
• Nakajima H, Asai A, Okada A, et al. (2004). "Transcriptional regulation of ILT family receptors". J. Immunol. 171 (12): 6611–20. doi:10.4049/jimmunol.171.12.6611. PMID 14662864.
• Papanikolaou NA, Vasilescu ER, Suciu-Foca N (2005). "Novel single nucleotide polymorphisms in the human immune inhibitory immunoglobulin-like T cell receptor type 4". Hum. Immunol. 65 (7): 700–5. doi:10.1016/j.humimm.2004.04.003. PMID 15301858.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• LILRB2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• LILRB2 human gene location in the UCSC Genome Browser.
• LILRB2 human gene details in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.