CD43

SPN
Identifiers
Aliases SPN, CD43, GALGP, GPL115, LSN, sialophorin
External IDs OMIM: 182160 MGI: 98384 HomoloGene: 36108 GeneCards: SPN
Orthologs
Species Human Mouse
Entrez

6693

20737

Ensembl

ENSG00000197471

ENSMUSG00000051457

UniProt

P16150

P15702

RefSeq (mRNA)

NM_001030288
NM_003123

NM_001037810
NM_009259

RefSeq (protein)

NP_001025459.1
NP_003114.1

NP_001032899.1
NP_033285.1

Location (UCSC) Chr 16: 29.66 – 29.67 Mb Chr 7: 127.13 – 127.14 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Leukosialin also known as sialophorin or CD43 (cluster of differentiation 43) is a transmembrane cell surface protein that in humans is encoded by the SPN (sialophorin) gene.[3][4][5]

Function

Sialophorin (leukosialin) is a major sialoglycoprotein on the surface of human T lymphocytes, monocytes, granulocytes, and some B lymphocytes, which appears to be important for immune function and may be part of a physiologic ligand-receptor complex involved in T-cell activation.[3]

Clinical significance

Defects in the CD43 molecule are associated with the development of Wiskott-Aldrich syndrome.[6] It also appears in about 25% of intestinal MALTomas. Using immunohistochemistry, CD43 can be demonstrated in the paracortical T-cells of healthy lymph nodes and tonsils; it is also positive in a range of lymphoid and myeloid tumours. Although it is present in over 90% of T-cell lymphomas, it is generally less effective at demonstrating this condition than is CD3 antigen. However, it may be useful as part of a panel to demonstrate B-cell lymphoblastic lymphoma, since the malignant cells in this condition are often CD43 positive, and may be difficult to stain with other antibodies. Because it stains granulocytes and their precursors, it is also an effective marker for myeloid tumours.[7]

Interactions

CD43 has been shown to interact with EZR[8] and Moesin.[8][9]

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. 1 2 "Entrez Gene: SPN sialophorin (leukosialin, CD43)".
  4. ↑ Pallant A, Eskenazi A, Mattei MG, Fournier RE, Carlsson SR, Fukuda M, Frelinger JG (February 1989). "Characterization of cDNAs encoding human leukosialin and localization of the leukosialin gene to chromosome 16". Proc. Natl. Acad. Sci. U.S.A. 86 (4): 1328–32. Bibcode:1989PNAS...86.1328P. doi:10.1073/pnas.86.4.1328. PMC 286683Freely accessible. PMID 2521952.
  5. ↑ Shelley CS, Remold-O'Donnell E, Davis AE, Bruns GA, Rosen FS, Carroll MC, Whitehead AS (April 1989). "Molecular characterization of sialophorin (CD43), the lymphocyte surface sialoglycoprotein defective in Wiskott-Aldrich syndrome". Proc. Natl. Acad. Sci. U.S.A. 86 (8): 2819–23. Bibcode:1989PNAS...86.2819S. doi:10.1073/pnas.86.8.2819. PMC 287010Freely accessible. PMID 2784859.
  6. ↑ Remold-O'Donnell E, Rosen FS (1990). "Sialophorin (CD43) and the Wiskott-Aldrich syndrome". Immunodefic Rev. 2 (2): 151–74. PMID 2223062.
  7. ↑ Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (2003). Manual of Diagnostic Cytology (2nd ed.). Greenwich Medical Media, Ltd. p. 113. ISBN 1-84110-100-1.
  8. 1 2 Serrador JM, Nieto M, Alonso-Lebrero JL, del Pozo MA, Calvo J, Furthmayr H, Schwartz-Albiez R, Lozano F, González-Amaro R, Sánchez-Mateos P, Sánchez-Madrid F (June 1998). "CD43 interacts with moesin and ezrin and regulates its redistribution to the uropods of T lymphocytes at the cell-cell contacts". Blood. 91 (12): 4632–44. PMID 9616160.
  9. ↑ Yonemura S, Hirao M, Doi Y, Takahashi N, Kondo T, Tsukita S, Tsukita S (February 1998). "Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2". J. Cell Biol. 140 (4): 885–95. doi:10.1083/jcb.140.4.885. PMC 2141743Freely accessible. PMID 9472040.

Further reading

External links


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