CD244

Not to be confused with KIR2DL4.

CD244

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1Z2K, 2PTT, 2PTU

Identifiers

Aliases

CD244, 2B4, NAIL, NKR2B4, Nmrk, SLAMF4, CD244 molecule

External IDs

MGI: 109294 HomoloGene: 9493 GeneCards: CD244

Gene ontology
Molecular function	• MHC class I protein binding • protein binding • receptor activity
Cellular component	• plasma membrane • membrane • integral component of membrane • external side of plasma membrane
Biological process	• myeloid dendritic cell activation • natural killer cell activation involved in immune response • innate immune response • positive regulation of granzyme B production • positive regulation of interleukin-8 secretion • positive regulation of CD8-positive, alpha-beta T cell proliferation • immune system process • leukocyte migration • positive regulation of natural killer cell proliferation • adaptive immune response • positive regulation of interferon-gamma secretion • signal transduction • positive regulation of inositol phosphate biosynthetic process • immune response
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


51744


18106

Ensembl


ENSG00000122223


ENSMUSG00000004709

UniProt


Q9BZW8


Q07763

RefSeq (mRNA)


NM_001166663 NM_001166664 NM_016382


NM_018729

RefSeq (protein)


NP_001160135.1 NP_001160136.1 NP_057466.1


NP_061199.2

Location (UCSC)

Chr 1: 160.83 – 160.86 Mb

Chr 1: 171.56 – 171.61 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

CD244 (Cluster of Differentiation 244) is a human protein encoded by the CD244 gene.^[3] It is also known as Natural Killer Cell Receptor 2B4^[4]

This gene encodes a cell surface receptor expressed on natural killer cells (NK cells) (and some T cells) mediating non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[5] CD244 can also be expressed on non-lymphocytes such as eosinophils, mast cells and dendritic cells.^[6]

References

Vaidya SV, Mathew PA (2006). "Of mice and men: different functions of the murine and human 2B4 (CD244) receptor on NK cells.". Immunol. Lett. 105 (2): 180–4. doi:10.1016/j.imlet.2006.02.006. PMID 16621032.
Siu G, Strauss EC, Lai E, Hood LE (1986). "Analysis of a human V beta gene subfamily". J. Exp. Med. 164 (5): 1600–14. doi:10.1084/jem.164.5.1600. PMC 2188445. PMID 3772297.
Latchman Y, McKay PF, Reiser H (1998). "Identification of the 2B4 molecule as a counter-receptor for CD48". J. Immunol. 161 (11): 5809–12. PMID 9834056.
Brown MH, Boles K, van der Merwe PA, et al. (1999). "2B4, the Natural Killer and T Cell Immunoglobulin Superfamily Surface Protein, Is a Ligand for CD48". J. Exp. Med. 188 (11): 2083–90. doi:10.1084/jem.188.11.2083. PMC 2212392. PMID 9841922.
Tangye SG, Lazetic S, Woollatt E, et al. (1999). "Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP". J. Immunol. 162 (12): 6981–5. PMID 10358138.
Nakajima H, Cella M, Langen H, et al. (1999). "Activating interactions in human NK cell recognition: the role of 2B4-CD48". Eur. J. Immunol. 29 (5): 1676–83. doi:10.1002/(SICI)1521-4141(199905)29:05<1676::AID-IMMU1676>3.0.CO;2-Y. PMID 10359122.
Boles KS, Nakajima H, Colonna M, et al. (1999). "Molecular characterization of a novel human natural killer cell receptor homologous to mouse 2B4". Tissue Antigens. 54 (1): 27–34. doi:10.1034/j.1399-0039.1999.540103.x. PMID 10458320.
Kubin MZ, Parshley DL, Din W, et al. (1999). "Molecular cloning and biological characterization of NK cell activation-inducing ligand, a counterstructure for CD48". Eur. J. Immunol. 29 (11): 3466–77. doi:10.1002/(SICI)1521-4141(199911)29:11<3466::AID-IMMU3466>3.0.CO;2-9. PMID 10556801.
Parolini S, Bottino C, Falco M, et al. (2000). "X-Linked Lymphoproliferative Disease: 2b4 Molecules Displaying Inhibitory Rather than Activating Function Are Responsible for the Inability of Natural Killer Cells to Kill Epstein-Barr Virus–Infected Cells". J. Exp. Med. 192 (3): 337–46. doi:10.1084/jem.192.3.337. PMC 2193227. PMID 10934222.
Kumaresan PR, Mathew PA (2000). "Structure of the human natural killer cell receptor 2B4 gene and identification of a novel alternative transcript". Immunogenetics. 51 (11): 987–92. doi:10.1007/s002510000237. PMID 11003394.
Watzl C, Stebbins CC, Long EO (2000). "NK cell inhibitory receptors prevent tyrosine phosphorylation of the activation receptor 2B4 (CD244)". J. Immunol. 165 (7): 3545–8. doi:10.4049/jimmunol.165.7.3545. PMID 11034353.
Tangye SG, Cherwinski H, Lanier LL, Phillips JH (2001). "2B4-mediated activation of human natural killer cells". Mol. Immunol. 37 (9): 493–501. doi:10.1016/S0161-5890(00)00076-6. PMID 11163399.
Chuang SS, Pham HT, Kumaresan PR, Mathew PA (2001). "A prominent role for activator protein-1 in the transcription of the human 2B4 (CD244) gene in NK cells". J. Immunol. 166 (10): 6188–95. doi:10.4049/jimmunol.166.10.6188. PMID 11342640.
Morra M, Simarro-Grande M, Martin M, et al. (2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients". J. Biol. Chem. 276 (39): 36809–16. doi:10.1074/jbc.M101305200. PMID 11477068.
Morra M, Lu J, Poy F, et al. (2001). "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells". EMBO J. 20 (21): 5840–52. doi:10.1093/emboj/20.21.5840. PMC 125701. PMID 11689425.
Speiser DE, Colonna M, Ayyoub M, et al. (2002). "The activatory receptor 2B4 is expressed in vivo by human CD8+ effector alpha beta T cells". J. Immunol. 167 (11): 6165–70. doi:10.4049/jimmunol.167.11.6165. PMID 11714776.
Chuang SS, Kumaresan PR, Mathew PA (2002). "2B4 (CD244)-mediated activation of cytotoxicity and IFN-gamma release in human NK cells involves distinct pathways". J. Immunol. 167 (11): 6210–6. doi:10.4049/jimmunol.167.11.6210. PMID 11714782.
Bottino C, Parolini S, Biassoni R, et al. (2002). "X-linked lymphoproliferative disease: the dark side of 2b4 function". Adv. Exp. Med. Biol. 495: 63–7. doi:10.1007/978-1-4615-0685-0_9. PMID 11774610.
Aoukaty A, Tan R (2002). "Association of the X-linked lymphoproliferative disease gene product SAP/SH2D1A with 2B4, a natural killer cell-activating molecule, is dependent on phosphoinositide 3-kinase". J. Biol. Chem. 277 (15): 13331–7. doi:10.1074/jbc.M112029200. PMID 11815622.
Sivori S, Falco M, Marcenaro E, et al. (2002). "Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation". Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4526–31. doi:10.1073/pnas.072065999. PMC 123681. PMID 11917118.
Assarsson E, Kambayshi T, Persson C, et al. (2005). "2B4 co-stimulation: NK cells and their control of adaptive immune responses". Mol.Immunol. 42 (4): 419–23. doi:10.1016/j.molimm.2004.07.021. PMID 15607793.

External links

CD244 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50

51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100

101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150

151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200

201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249

251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299

301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

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CD244

See also

References

Further reading

External links