LILRA2

LILRA2
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2OTP
Identifiers
Aliases	LILRA2, CD85H, ILT1, LIR-7, LIR7, leukocyte immunoglobulin like receptor A2
External IDs	HomoloGene: 68534 GeneCards: LILRA2
Gene ontology Molecular function • antigen binding • receptor activity Cellular component • integral component of membrane • extracellular region • membrane Biological process • defense response • adaptive immune response • signal transduction • immune system process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11027	n/a
Ensembl	n/a	n/a
UniProt	Q8N149	n/a
RefSeq (mRNA)	NM_001130917 NM_001290270 NM_001290271 NM_006866	n/a
RefSeq (protein)	NP_006857.2	n/a
Location (UCSC)	Chr 19: 54.57 – 54.59 Mb	n/a
PubMed search	[1]	n/a
Wikidata

View/Edit Human

Leukocyte immunoglobulin-like receptor subfamily A member 2 (LILRA2, CD85H, ILT1) is a protein that in humans is encoded by the LILRA2 gene.^[2][3][4]

Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells. All LIRs in subfamily B have an inhibitory function (see, e.g., LILRB1, MIM 604811). LIRs in subfamily A, with short cytoplasmic domains lacking an immunoreceptor tyrosine-based inhibitory motif (ITIM) and with transmembrane regions containing a charged arginine residue, may initiate stimulatory cascades. One member of subfamily A (LILRA3; MIM 604818) lacks a transmembrane region and is presumed to be a soluble receptor.[supplied by OMIM]^[4]

Function

LILRA2 senses microbially cleaved immunoglobulin to activate human myeloid cells.^[5]

See also

• Cluster of differentiation

References

1. "Human PubMed Reference:".
2. Samaridis J, Colonna M (Apr 1997). "Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways". Eur J Immunol. 27 (3): 660–5. doi:10.1002/eji.1830270313. PMID 9079806.
3. Borges L, Hsu ML, Fanger N, Kubin M, Cosman D (Apr 1998). "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules". J Immunol. 159 (11): 5192–6. PMID 9548455.
4. "Entrez Gene: LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2".
5. Hirayasu K, Saito F, Suenaga T, Shida K, Arase N, Oikawa K, Yamaoka T, Murota H, Chibana H, Nagai H, Nakamura Y, Katayama I, Colonna M, Arase H (Apr 2016). "LILRA2 is an innate immune sensor for microbially cleaved immunoglobulins". Nature Microbiology. 1 (6): 16054. doi:10.1038/NMICROBIOL.2016.54.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Rojo S, Burshtyn DN, Long EO, Wagtmann N (1997). "Type I transmembrane receptor with inhibitory function in mouse mast cells and NK cells.". J. Immunol. 158 (1): 9–12. PMID 8977169.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene. 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tedla N, Bandeira-Melo C, Tassinari P, et al. (2003). "Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7.". Proc. Natl. Acad. Sci. U.S.A. 100 (3): 1174–9. doi:10.1073/pnas.0337567100. PMC 298746. PMID 12529506.
• Nakajima H, Asai A, Okada A, et al. (2004). "Transcriptional regulation of ILT family receptors.". J. Immunol. 171 (12): 6611–20. doi:10.4049/jimmunol.171.12.6611. PMID 14662864.
• Sloane DE, Tedla N, Awoniyi M, et al. (2004). "Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition.". Blood. 104 (9): 2832–9. doi:10.1182/blood-2004-01-0268. PMID 15242876.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• LILRA2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.