Transferrin receptor 1

TFRC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CX8, 1DE4, 1SUV, 2NSU, 3KAS, 3S9L, 3S9M, 3S9N
Identifiers
Aliases	TFRC, CD71, T9, TFR, TFR1, TR, TRFR, p90, IMD46, transferrin receptor
External IDs	MGI: 98822 HomoloGene: 2429 GeneCards: TFRC
Gene ontology Molecular function • protein homodimerization activity • virus receptor activity • glycoprotein binding • transferrin receptor activity • protein binding • identical protein binding • double-stranded RNA binding • poly(A) RNA binding • transferrin transmembrane transporter activity Cellular component • extracellular vesicle • integral component of membrane • recycling endosome • HFE-transferrin receptor complex • endosome • blood microparticle • membrane • intracellular membrane-bounded organelle • melanosome • plasma membrane • integral component of plasma membrane • cytoplasmic, membrane-bounded vesicle • extracellular fluid • extracellular region • cell surface • basolateral plasma membrane • perinuclear region of cytoplasm • clathrin-coated pit • extracellular exosome • external side of plasma membrane Biological process • endocytosis • osteoclast differentiation • positive regulation of bone resorption • receptor-mediated endocytosis • iron ion import • cellular response to drug • regulation of cell proliferation • regulation of cell growth • viral entry into host cell • viral process • cellular iron ion homeostasis • positive regulation of isotype switching • receptor internalization • transferrin transport • positive regulation of B cell proliferation • positive regulation of T cell proliferation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7037	22042
Ensembl	ENSG00000072274	ENSMUSG00000022797
UniProt	P02786	Q62351
RefSeq (mRNA)	NM_001313965 NM_001313966 NM_001128148 NM_003234	NM_011638
RefSeq (protein)	NP_001121620.1 NP_003225.2 NP_001300894.1 NP_001300895.1	NP_035768.1
Location (UCSC)	Chr 3: 196.03 – 196.08 Mb	Chr 16: 32.61 – 32.63 Mb
PubMed search	[1]	[2]
Wikidata

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Transferrin receptor protein 1 (TfR1), also known as Cluster of Differentiation 71 (CD71), is a protein that in humans is encoded by the TFRC gene.^[3][4] TfR1 is required for iron import from transferrin into cells by endocytosis.^[5][6]

Structure and function

TfR1 = transferrin receptor 1 in Human iron metabolism.

TfR1 is a transmembrane glycoprotein composed of two disulfide-linked monomers joined by two disulfide bonds. Each monomer binds one holo-transferrin molecule creating an iron-Tf-TfR complex which enters the cell by endocytosis.^[7]

Clinical significance

TfR1 as a potential new target in cases of human leukemia & lymphoma. InatherYs, in Évry, France, developed a candidate drug, INA01 antibody (anti-CD71) that showed efficacy in pre-clinical studies in the therapy of two incurable orphan oncohematological diseases: the adult T cell leukemia (ATLL) caused by HTLV-1 and the Mantle cell lymphoma (MCL).

Interactions

TfR1 has been shown to interact with GABARAP^[8] and HFE.^[9][10]

See also

• Transferrin receptor 2
• Cluster of differentiation

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Sutherland R, Delia D, Schneider C, Newman R, Kemshead J, Greaves M (July 1981). "Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin". Proc. Natl. Acad. Sci. U.S.A. 78 (7): 4515–9. doi:10.1073/pnas.78.7.4515. PMC 319822. PMID 6270680.
4. Rabin M, McClelland A, Kühn L, Ruddle FH (November 1985). "Regional localization of the human transferrin receptor gene to 3q26.2----qter". Am. J. Hum. Genet. 37 (6): 1112–6. PMC 1684729. PMID 3002171.
5. Aisen P (November 2004). "Transferrin receptor 1". Int. J. Biochem. Cell Biol. 36 (11): 2137–43. doi:10.1016/j.biocel.2004.02.007. PMID 15313461.
6. Moos T (November 2002). "Brain iron homeostasis". Danish Medical Bulletin. 49 (4): 279–301. PMID 12553165.
7. Speeckaert MM, Speeckaert R, Delanghe JR (December 2010). "Biological and clinical aspects of soluble transferrin receptor". Critical Reviews in Clinical Laboratory Sciences. 47 (5-6): 213–228. doi:10.3109/10408363.2010.550461. PMID 21391831.
8. Green F, O'Hare T, Blackwell A, Enns CA (May 2002). "Association of human transferrin receptor with GABARAP". FEBS Lett. 518 (1–3): 101–6. doi:10.1016/S0014-5793(02)02655-8. PMID 11997026.
9. Feder JN, Penny DM, Irrinki A, Lee VK, Lebrón JA, Watson N, Tsuchihashi Z, Sigal E, Bjorkman PJ, Schatzman RC (February 1998). "The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding". Proc. Natl. Acad. Sci. U.S.A. 95 (4): 1472–7. doi:10.1073/pnas.95.4.1472. PMC 19050. PMID 9465039.
10. West AP, Bennett MJ, Sellers VM, Andrews NC, Enns CA, Bjorkman PJ (December 2000). "Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE". J. Biol. Chem. 275 (49): 38135–8. doi:10.1074/jbc.C000664200. PMID 11027676.