LY75

LY75
Identifiers
Aliases	LY75, CD205, CLEC13B, DEC-205, GP200-MR6, LY-75, lymphocyte antigen 75
External IDs	MGI: 106662 HomoloGene: 31085 GeneCards: LY75
Gene ontology Molecular function • protein binding • carbohydrate binding • receptor activity Cellular component • integral component of membrane • integral component of plasma membrane • extracellular exosome • membrane Biological process • inflammatory response • endocytosis • immune response Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4065	17076
Ensembl	ENSG00000054219	ENSMUSG00000026980
UniProt	O60449	Q60767
RefSeq (mRNA)	NM_002349	NM_013825
RefSeq (protein)	NP_001185688.1 NP_001185689.1 NP_002340.2	NP_038853.2
Location (UCSC)	Chr 2: 159.8 – 159.9 Mb	Chr 2: 60.29 – 60.38 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Lymphocyte antigen 75 is a protein that in humans is encoded by the LY75 gene.^[3][4]

LY75 has also recently been designated CD205 (cluster of differentiation 205). CD205 is also known as DEC-205.

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Kato M, Neil TK, Clark GJ, Morris CM, Sorg RV, Hart DN (Jun 1998). "cDNA cloning of human DEC-205, a putative antigen-uptake receptor on dendritic cells". Immunogenetics. 47 (6): 442–50. doi:10.1007/s002510050381. PMID 9553150.
4. "Entrez Gene: LY75 lymphocyte antigen 75".

Further reading

• Tungekar MF, Gatter KC, Ritter MA (1996). "Bladder carcinomas and normal urothelium universally express gp200-MR6, a molecule functionally associated with the interleukin 4 receptor (CD 124)". Br. J. Cancer. 73 (4): 429–32. doi:10.1038/bjc.1996.77. PMC 2074450. PMID 8595155.
• al-Tubuly AA, Luqmani YA, Shousha S, et al. (1996). "Differential expression of gp200-MR6 molecule in benign hyperplasia and down-regulation in invasive carcinoma of the breast". Br. J. Cancer. 74 (7): 1005–11. doi:10.1038/bjc.1996.481. PMC 2077117. PMID 8855966.
• McKay PF, Imami N, Johns M, et al. (1999). "The gp200-MR6 molecule which is functionally associated with the IL-4 receptor modulates B cell phenotype and is a novel member of the human macrophage mannose receptor family". Eur. J. Immunol. 28 (12): 4071–83. doi:10.1002/(SICI)1521-4141(199812)28:12<4071::AID-IMMU4071>3.0.CO;2-O. PMID 9862343.
• Palmer DB, Crompton T, Marandi MB, et al. (1999). "Intrathymic function of the human cortical epithelial cell surface antigen gp200-MR6: single-chain antibodies to evolutionarily conserved determinants disrupt mouse thymus development". Immunology. 96 (2): 236–45. doi:10.1046/j.1365-2567.1999.00691.x. PMC 2326733. PMID 10233701.
• Guo M, Gong S, Maric S, et al. (2000). "A monoclonal antibody to the DEC-205 endocytosis receptor on human dendritic cells". Hum. Immunol. 61 (8): 729–38. doi:10.1016/S0198-8859(00)00144-0. PMID 10980384.
• Kato M, Neil TK, Fearnley DB, et al. (2000). "Expression of multilectin receptors and comparative FITC-dextran uptake by human dendritic cells". Int. Immunol. 12 (11): 1511–9. doi:10.1093/intimm/12.11.1511. PMID 11058570.
• Kato M, Khan S, Gonzalez N, et al. (2003). "Hodgkin's lymphoma cell lines express a fusion protein encoded by intergenically spliced mRNA for the multilectin receptor DEC-205 (CD205) and a novel C-type lectin receptor DCL-1". J. Biol. Chem. 278 (36): 34035–41. doi:10.1074/jbc.M303112200. PMID 12824192.
• Bozzacco L, Trumpfheller C, Siegal FP, et al. (2007). "DEC-205 receptor on dendritic cells mediates presentation of HIV gag protein to CD8+ T cells in a spectrum of human MHC I haplotypes". Proc. Natl. Acad. Sci. U.S.A. 104 (4): 1289–94. doi:10.1073/pnas.0610383104. PMC 1783096. PMID 17229838.
• Nonaka D, Henley JD, Chiriboga L, Yee H (2007). "Diagnostic utility of thymic epithelial markers CD205 (DEC205) and Foxn1 in thymic epithelial neoplasms". Am. J. Surg. Pathol. 31 (7): 1038–44. doi:10.1097/PAS.0b013e31802b4917. PMID 17592270.