CLEC4M

CLEC4M
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1K9J, 1SL6, 1XAR, 1XPH, 3JQH
Identifiers
Aliases	CLEC4M, CD209L, CD299, DC-SIGN2, DC-SIGNR, DCSIGNR, HP10347, L-SIGN, LSIGN, C-type lectin domain family 4 member M
External IDs	MGI: 2157942 HomoloGene: 129771 GeneCards: CLEC4M
Gene ontology Molecular function • peptide antigen binding • virus receptor activity • metal ion binding • calcium-dependent protein binding • mannose binding • virion binding • ICAM-3 receptor activity • carbohydrate binding • receptor activity Cellular component • cytoplasm • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • extracellular region Biological process • leukocyte cell-cell adhesion • cell-cell recognition • intracellular transport of virus • intracellular signal transduction • antigen processing and presentation • endocytosis • adaptive immune response • immune system process • viral genome replication • peptide antigen transport • modulation by virus of host morphology or physiology • regulation of gene expression • regulation of blood coagulation • innate immune response • viral process • virion attachment to host cell • viral entry into host cell Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10332	170786
Ensembl	ENSG00000104938	ENSMUSG00000031494
UniProt	Q9H2X3	Q91ZX1
RefSeq (mRNA)	NM_001144904 NM_001144905 NM_001144906 NM_001144907 NM_001144908 NM_001144909 NM_001144910 NM_001144911 NM_014257 NM_214675 NM_214676	NM_133238
RefSeq (protein)	NP_001138377.1 NP_001138378.1 NP_001138379.1 NP_001138380.1 NP_001138381.1 NP_001138382.1 NP_001138383.1 NP_055072.3	NP_573501.1
Location (UCSC)	Chr 19: 7.76 – 7.77 Mb	Chr 8: 3.74 – 3.75 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

C-type lectin domain family 4 member M is a protein that in humans is encoded by the CLEC4M gene.^[3] CLEC4M has also been designated as CD299 (cluster of differentiation 299).

This gene encodes L-SIGN (liver/lymph node-specific intracellular adhesion molecules-3 grabbing non-integrin), a type II integral membrane protein that is 77% identical to CD209 antigen, an HIV gp120-binding protein. This protein, like CD209, efficiently binds both intercellular adhesion molecule 3 (ICAM3) and HIV-1 gp120, and enhances HIV-1 infection of T cells. This gene is mapped to 19p13.3, in a cluster with the CD209 and CD23/FCER2 genes. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.^[4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Yokoyama-Kobayashi M, Yamaguchi T, Sekine S, Kato S (Apr 1999). "Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank". Gene. 228 (1-2): 161–7. doi:10.1016/S0378-1119(99)00004-9. PMID 10072769.
4. "Entrez Gene: CLEC4M C-type lectin domain family 4, member M".

Further reading

• Baribaud F, Doms RW, Pöhlmann S (2006). "The role of DC-SIGN and DC-SIGNR in HIV and Ebola virus infection: can potential therapeutics block virus transmission and dissemination?". Expert Opin. Ther. Targets. 6 (4): 423–31. doi:10.1517/14728222.6.4.423. PMID 12223058.
• Becker Y (2004). "HIV-1 gp120 binding to dendritic cell receptors mobilize the virus to the lymph nodes, but the induced IL-4 synthesis by FcepsilonRI+ hematopoietic cells damages the adaptive immunity--a review, hypothesis, and implications.". Virus Genes. 29 (1): 147–65. doi:10.1023/B:VIRU.0000032797.43537.d3. PMID 15215692.
• Lalor PF, Lai WK, Curbishley SM, et al. (2006). "Human hepatic sinusoidal endothelial cells can be distinguished by expression of phenotypic markers related to their specialised functions in vivo.". World J. Gastroenterol. 12 (34): 5429–39. PMID 17006978.
• Curtis BM, Scharnowske S, Watson AJ (1992). "Sequence and expression of a membrane-associated C-type lectin that exhibits CD4-independent binding of human immunodeficiency virus envelope glycoprotein gp120.". Proc. Natl. Acad. Sci. U.S.A. 89 (17): 8356–60. doi:10.1073/pnas.89.17.8356. PMC 49917. PMID 1518869.
• Gattegno L, Ramdani A, Jouault T, et al. (1992). "Lectin-carbohydrate interactions and infectivity of human immunodeficiency virus type 1 (HIV-1).". AIDS Res. Hum. Retroviruses. 8 (1): 27–37. doi:10.1089/aid.1992.8.27. PMID 1736938.
• Soilleux EJ, Barten R, Trowsdale J (2000). "DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on 19p13.". J. Immunol. 165 (6): 2937–42. doi:10.4049/jimmunol.165.6.2937. PMID 10975799.
• Pöhlmann S, Soilleux EJ, Baribaud F, et al. (2001). "DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans.". Proc. Natl. Acad. Sci. U.S.A. 98 (5): 2670–5. doi:10.1073/pnas.051631398. PMC 30196. PMID 11226297.
• Bashirova AA, Geijtenbeek TB, van Duijnhoven GC, et al. (2001). "A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection.". J. Exp. Med. 193 (6): 671–8. doi:10.1084/jem.193.6.671. PMC 2193415. PMID 11257134.
• Mummidi S, Catano G, Lam L, et al. (2001). "Extensive repertoire of membrane-bound and soluble dendritic cell-specific ICAM-3-grabbing nonintegrin 1 (DC-SIGN1) and DC-SIGN2 isoforms. Inter-individual variation in expression of DC-SIGN transcripts.". J. Biol. Chem. 276 (35): 33196–212. doi:10.1074/jbc.M009807200. PMID 11337487.
• Mitchell DA, Fadden AJ, Drickamer K (2001). "A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligands.". J. Biol. Chem. 276 (31): 28939–45. doi:10.1074/jbc.M104565200. PMID 11384997.
• Feinberg H, Mitchell DA, Drickamer K, Weis WI (2002). "Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR.". Science. 294 (5549): 2163–6. doi:10.1126/science.1066371. PMID 11739956.
• Alvarez CP, Lasala F, Carrillo J, et al. (2002). "C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans.". J. Virol. 76 (13): 6841–4. doi:10.1128/JVI.76.13.6841-6844.2002. PMC 136246. PMID 12050398.
• Soilleux EJ, Morris LS, Rushbrook S, et al. (2002). "Expression of human immunodeficiency virus (HIV)-binding lectin DC-SIGNR: Consequences for HIV infection and immunity.". Hum. Pathol. 33 (6): 652–9. doi:10.1053/hupa.2002.124036. PMID 12152166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lin G, Simmons G, Pöhlmann S, et al. (2003). "Differential N-linked glycosylation of human immunodeficiency virus and Ebola virus envelope glycoproteins modulates interactions with DC-SIGN and DC-SIGNR.". J. Virol. 77 (2): 1337–46. doi:10.1128/JVI.77.2.1337-1346.2003. PMC 140807. PMID 12502850.
• Pöhlmann S, Zhang J, Baribaud F, et al. (2003). "Hepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNR.". J. Virol. 77 (7): 4070–80. doi:10.1128/JVI.77.7.4070-4080.2003. PMC 150620. PMID 12634366.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Engering A, van Vliet SJ, Hebeda K, et al. (2004). "Dynamic populations of dendritic cell-specific ICAM-3 grabbing nonintegrin-positive immature dendritic cells and liver/lymph node-specific ICAM-3 grabbing nonintegrin-positive endothelial cells in the outer zones of the paracortex of human lymph nodes.". Am. J. Pathol. 164 (5): 1587–95. doi:10.1016/S0002-9440(10)63717-0. PMC 1615649. PMID 15111305.

External links

• CLEC4M protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• CLEC4M human gene location in the UCSC Genome Browser.
• CLEC4M human gene details in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.