Lu AA-33810

Lu AA-33810

Clinical data
ATC code	None
Identifiers
IUPAC name N-[(trans-4-[(4,5-Dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl)methyl]methanesulfonamide
Synonyms	Lu AA-33810
PubChem (CID)	22254068
ChemSpider	21223462
ChEMBL	CHEMBL1836317
Chemical and physical data
Formula	C19H25N3O2S3
Molar mass	423.615 g/mol
3D model (Jmol)	Interactive image
SMILES O=S(C)(=O)NCC3CCC(CC3)Nc4sc2CCSc1ccccc1-c2n4
InChI InChI=1S/C19H25N3O2S3/c1-27(23,24)20-12-13-6-8-14(9-7-13)21-19-22-18-15-4-2-3-5-16(15)25-11-10-17(18)26-19/h2-5,13-14,20H,6-12H2,1H3,(H,21,22) Key:UWSBTSAJZMIHBL-UHFFFAOYSA-N
(verify)

Lu AA-33810 is a drug developed by Lundbeck, which acts as a potent and highly selective antagonist for the Neuropeptide Y receptor Y₅, with a Ki of 1.5nM and around 3300x selectivity over the related Y₁, Y₂ and Y₄ receptors. In animal studies it produced anorectic, antidepressant and anxiolytic effects, and further research is now being conducted into its possible medical application in the treatment of eating disorders.^[1]

References

1. Walker MW, Wolinsky TD, Jubian V, Chandrasena G, Zhong H, Huang X, Miller S, Hegde LG, Marsteller DA, Marzabadi MR, Papp M, Overstreet DH, Gerald CP, Craig DA (March 2009). "The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 (N-([trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl)-methanesulfonamide) exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity". The Journal of Pharmacology and Experimental Therapeutics. 328 (3): 900–11. doi:10.1124/jpet.108.144634. PMID 19098165.