Olcegepant

Olcegepant

Clinical data
ATC code	None
Identifiers
IUPAC name N-{(2S)-6-Amino-1-oxo-1-[4-(4-pyridinyl)-1-piperazinyl]-2-hexanyl}-3,5-dibromo-Nα-{[4-(2-oxo-1,4-dihydro-3(2H)-quinazolinyl)-1-piperidinyl]carbonyl}-D-tyrosinamide
CAS Number	204697-65-4
PubChem (CID)	6918509
ChemSpider	5293706
Chemical and physical data
Formula	C38H47Br2N9O5
Molar mass	869.645 g/mol
3D model (Jmol)	Interactive image
SMILES C1CN(CCC1N2CC3=CC=CC=C3NC2=O)C(=O)N[C@H](CC4=CC(=C(C(=C4)Br)O)Br)C(=O)N[C@@H](CCCCN)C(=O)N5CCN(CC5)C6=CC=NC=C6
InChI InChI=1S/C38H47Br2N9O5/c39-29-21-25(22-30(40)34(29)50)23-33(45-37(53)48-15-10-28(11-16-48)49-24-26-5-1-2-6-31(26)44-38(49)54)35(51)43-32(7-3-4-12-41)36(52)47-19-17-46(18-20-47)27-8-13-42-14-9-27/h1-2,5-6,8-9,13-14,21-22,28,32-33,50H,3-4,7,10-12,15-20,23-24,41H2,(H,43,51)(H,44,54)(H,45,53)/t32-,33+/m0/s1 Key:ITIXDWVDFFXNEG-JHOUSYSJSA-N

Olcegepant (INN) (code name BIBN-4096BS) is a calcitonin gene-related peptide receptor antagonist being studied as a potential treatment for migraines.^[1]

A 2013 meta-analysis found olcegepant and telcagepant were effective and safe compared to placebo.^[2]

See also

• Telcagepant

References

1. Tfelt-Hansen, P; Olesen, J (Apr 2011). "Possible site of action of CGRP antagonists in migraine.". Cephalalgia : an international journal of headache. 31 (6): 748–50. doi:10.1177/0333102411398403. PMID 21383046.
2. Yao, Gang; Yu, Tingmin; Han, Ximei; Mao, Xijing; Li, Bo (2013-04-05). "Therapeutic effects and safety of olcegepant and telcagepant for migraine: A meta-analysis". Neural Regeneration Research. 8 (10): 938–947. doi:10.3969/j.issn.1673-5374.2013.10.009. ISSN 1673-5374. PMC 4145922. PMID 25206386.