Endothelin 1

EDN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1EDN, 1EDP, 1T7H, 1V6R
Identifiers
Aliases	EDN1, ARCND3, ET1, HDLCQ7, PPET1, QME, endothelin 1
External IDs	MGI: 95283 HomoloGene: 1476 GeneCards: EDN1
Gene ontology Molecular function • hormone activity • receptor binding • cytokine activity • endothelin B receptor binding • protein binding • endothelin A receptor binding Cellular component • cytoplasm • Weibel-Palade body • basal part of cell • extracellular region • extracellular space • rough endoplasmic reticulum lumen Biological process • skeletal system development • response to amino acid • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway • negative regulation of cellular protein metabolic process • positive regulation of MAP kinase activity • regulation of sensory perception of pain • vasoconstriction • body fluid secretion • positive regulation of sarcomere organization • positive regulation of cardiac muscle hypertrophy • cell surface receptor signaling pathway • cellular response to drug • multicellular organism aging • artery smooth muscle contraction • cellular response to interferon-gamma • positive regulation of chemokine-mediated signaling pathway • phosphatidylinositol 3-kinase signaling • response to leptin • positive regulation of mitotic nuclear division • cellular response to hypoxia • response to muscle stretch • cellular response to calcium ion • cellular response to transforming growth factor beta stimulus • regulation of blood vessel size • positive regulation of renal sodium excretion • blood vessel morphogenesis • negative regulation of blood coagulation • response to nicotine • in utero embryonic development • neutrophil chemotaxis • cell growth • heart development • positive regulation of prostaglandin secretion • vein smooth muscle contraction • cartilage development • rhythmic excitation • protein kinase C-activating G-protein coupled receptor signaling pathway • cellular response to glucocorticoid stimulus • negative regulation of cAMP biosynthetic process • branching involved in blood vessel morphogenesis • negative regulation of hormone secretion • positive regulation of smooth muscle contraction • negative regulation of nitric-oxide synthase biosynthetic process • positive regulation of prostaglandin-endoperoxide synthase activity • G-protein coupled receptor signaling pathway • positive regulation of urine volume • positive regulation of JUN kinase activity • leukocyte activation • positive regulation of receptor biosynthetic process • membrane depolarization • negative regulation of transcription from RNA polymerase II promoter • response to ozone • respiratory gaseous exchange • positive regulation of heart rate • regulation of blood pressure • response to lipopolysaccharide • response to prostaglandin F • regulation of vasoconstriction • cellular response to interleukin-1 • response to salt • positive regulation of cell size • middle ear morphogenesis • sensory perception of pain • prostaglandin biosynthetic process • dorsal/ventral pattern formation • phospholipase D-activating G-protein coupled receptor signaling pathway • positive regulation of odontogenesis • regulation of pH • positive regulation of smooth muscle cell proliferation • protein kinase C deactivation • histamine secretion • maternal process involved in parturition • intracellular signal transduction • response to hypoxia • neural crest cell development • regulation of systemic arterial blood pressure by endothelin • nitric oxide transport • positive regulation of cell migration • response to testosterone • positive regulation of cytosolic calcium ion concentration • epithelial fluid transport • positive regulation of nitric oxide biosynthetic process • cell-cell signaling • cellular response to tumor necrosis factor • response to activity • response to dexamethasone • superoxide anion generation • positive regulation of endothelial cell migration • cellular response to peptide hormone stimulus • cellular response to fatty acid • peptide hormone secretion • cellular response to mineralocorticoid stimulus • positive regulation of cell proliferation • inositol phosphate-mediated signaling • positive regulation of hormone secretion • negative regulation of smooth muscle cell apoptotic process • response to drug • glucose transport • calcium-mediated signaling • response to transforming growth factor beta • positive regulation of transcription from RNA polymerase II promoter • positive regulation of sequence-specific DNA binding transcription factor activity • positive regulation of cell growth involved in cardiac muscle cell development Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1906	13614
Ensembl	ENSG00000078401	ENSMUSG00000021367
UniProt	P05305	P22387
RefSeq (mRNA)	NM_001168319 NM_001955	NM_010104
RefSeq (protein)	NP_001161791.1 NP_001946.3	NP_034234.1
Location (UCSC)	Chr 6: 12.29 – 12.3 Mb	Chr 13: 42.3 – 42.31 Mb
PubMed search	[1]	[2]
Wikidata

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Endothelin 1 (ET-1), also known as preproendothelin-1 (PPET1), is a protein that in humans is encoded by the EDN1 gene. The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 is one of three isoforms of human endothelin.

Preproendothelin is precursor of the peptide ET-1. Endothelial cells convert preproendothelin to proendothelin and subsequently to mature endothelin, which the cells release.^[3]

Endothelin-1 receptor antagonists (Bosentan) are used in the treatment of pulmonary hypertension. Inhibition of these receptors prevents pulmonary vasculature constriction and thus decreases pulmonary vascular resistance.

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Boulpaep EL, Boron WF (2009). Medical physiology: a cellular and molecular approach. Saunders/Elsevier. ISBN 1-4160-3115-4.

Further reading

• Bruno CM, Neri S, Di Prima P, Sciacca C (2003). "Pathophysiology of endothelin and medical emergencies.". Panminerva medica. 45 (2): 151–4. PMID 12855940.
• Doggrell SA (2006). "The endothelin system and its role in acute myocardial infarction.". Expert Opin. Ther. Targets. 8 (3): 191–201. doi:10.1517/14728222.8.3.191. PMID 15161426.
• Beghetti M, Black SM, Fineman JR (2005). "Endothelin-1 in congenital heart disease.". Pediatr. Res. 57 (5 Pt 2): 16R–20R. doi:10.1203/01.PDR.0000160447.83332.13. PMID 15817494.
• Cazaubon S, Deshayes F, Couraud PO, Nahmias C (2006). "[Endothelin-1, angiotensin II and cancer]". Med Sci (Paris). 22 (4): 416–22. doi:10.1051/medsci/2006224416. PMID 16597412.
• Ariza AC, Bobadilla NA, Halhali A (2007). "[Endothelin 1 and angiotensin II in preeeclampsia]". Rev. Invest. Clin. 59 (1): 48–56. PMID 17569300.
• Davenport AP, Hyndman KA, Dhaun N, Southan C, Kohan DE, Pollock JS, Pollock DM, Webb DJ, Maguire JJ (April 2016). "Endothelin". Pharmacological Reviews. 68 (2): 357–418. doi:10.1124/pr.115.011833. PMID 26956245.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.