Adiponectin receptor 2

ADIPOR2
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3WXW
Identifiers
Aliases	ADIPOR2, adiponectin receptor 2, ACDCR2, PAQR2
External IDs	HomoloGene: 56119 GeneCards: ADIPOR2
Gene ontology Molecular function • adipokinetic hormone receptor activity • adiponectin binding • metal ion binding • identical protein binding • protein heterodimerization activity • receptor activity Cellular component • integral component of membrane • membrane • intrinsic component of plasma membrane • plasma membrane Biological process • positive regulation of glucose import • glucose homeostasis • response to nutrient • lipid metabolic process • female pregnancy • adiponectin-activated signaling pathway • fatty acid metabolic process • vascular wound healing • heart development • negative regulation of cell growth • fatty acid oxidation • hormone-mediated signaling pathway • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79602	n/a
Ensembl	ENSG00000006831	n/a
UniProt	Q86V24	n/a
RefSeq (mRNA)	NM_024551	n/a
RefSeq (protein)	NP_078827.2	n/a
Location (UCSC)	Chr 12: 1.69 – 1.79 Mb	n/a
PubMed search	[1]	n/a
Wikidata

View/Edit Human

Adiponectin receptor 2 (AdipoR2) is a protein which in humans is encoded by the ADIPOR2 gene.^[2] It is a member of the progestin and adipoQ receptor (PAQR) family, and is also known as PAQR2.^[3]

Structure

Similar to G protein-coupled receptors (GPCRs), AdipoR2 also possesses 7 transmembrane domains. However, AdipoR2 is orientated oppositely to GPCRs in the membrane (i.e., cytoplasmic N-terminus, extracellular C-terminus) and does not associate with G proteins.^[2]

Function

The adiponectin receptors, AdipoR1 and AdipoR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-α ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin.^[2]

Ligands

Agonists

Peptide

• Adiponectin
• ADP-355^[4]
• ADP-399^[4]

Non-peptide

• AdipoRon^[5]
• Deoxyschizandrin^[6]
• Parthenolide^[6]
• Syringing^[6]
• Taxifoliol^[6]

Antagonists

Peptide

• ADP-400^[4]

See also

• Adiponectin receptor
• Adiponectin receptor 1

References

1. "Human PubMed Reference:".
2. Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T (June 2003). "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature. 423 (6941): 762–9. doi:10.1038/nature01705. PMID 12802337.
3. Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, Funk WD (September 2005). "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif". Journal of Molecular Evolution. 61 (3): 372–80. doi:10.1007/s00239-004-0375-2. PMID 16044242.
4. Otvos L, Knappe D, Hoffmann R, Kovalszky I, Olah J, Hewitson TD, Stawikowska R, Stawikowski M, Cudic P, Lin F, Wade JD, Surmacz E, Lovas S (2014). "Development of second generation peptides modulating cellular adiponectin receptor responses". Frontiers in Chemistry. 2: 93. doi:10.3389/fchem.2014.00093. PMC 4201147. PMID 25368867.
5. Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T, Tanaka A, Yokoyama S, Kadowaki T (November 2013). "A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity". Nature. 503 (7477): 493–9. doi:10.1038/nature12656. PMID 24172895.
6. Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Lin D, Zhao Y, Zhang Z (2013). "Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay". PloS One. 8 (5): e63354. doi:10.1371/journal.pone.0063354. PMC 3653934. PMID 23691032.